亚临床甲状腺功能减退症患者的高敏 C 反应蛋白和血脂谱改变与心血管风险评估。

High Sensitive C-Reactive Protein and Lipid Profile Alteration In Subclinical Hypothyroidism for Cardiovascular Risk Assessment.

机构信息

Department of Clinical Biochemistry, Maharajgunj Medical Campus, Institute of Medicine,Tribhuvan University Teaching Hospital, Maharajgunj, Kathmandu, Nepal.

Department of Internal Medicine (Endocrinology), Maharajgunj Medical Campus, Institute of Medicine, Tribhuvan University Teaching Hospital, Maharajgunj, Kathmandu, Nepal.

出版信息

J Nepal Health Res Counc. 2024 Oct 3;22(2):306-310. doi: 10.33314/jnhrc.v22i02.5383.

DOI:10.33314/jnhrc.v22i02.5383

PMID:39572949

Abstract

BACKGROUND

The purpose of this study was to investigate the association of subclinical hypothyroidism with High sensitive C-reactive protein and lipid profile which can predispose to development of Cardiovascular disease.

METHODS

This hospital-based comparative cross-sectional study was conducted for a period of six months. A total of 71 patients with subclinical hypothyroidism and 37 healthy control subjects were enrolled for the study. Thyroid hormones, lipid profile, hs- CRP were measured and lipid variables were used to calculate lipid indices. Student t-test were used to compare means and Spearmans correlation was done to determine the association between variables. ROC curve analysis was used to determine the diagnostic value of tests.

RESULTS

Out of 71 cases and 37 control, majority had female preponderance (71.8% in case and 83.8% in control). The mean values between case and control groups for High sensitive C-Reactive Protein, Atherogenic index of plasma, Lipoprotein combined index and non-High Density Lipoprotein cholesterol were statistically significant. There was positive correlation between Thyroid Stimulating Hormone and High sensitive C-Reactive Protein r=0.492, p 0.001, Atherogenic index of plasma and Thyroid Stimulating Hormone r=0.430, p 0.001, Lipoprotein combined index and Thyroid Stimulating Hormone (r=0.269, p =0.005), Thyroid Stimulating Hormone and non-High Density Lipoprotein cholesterol (r=0.308, p=0.001) and Atherogenic Index and Low Density Lipoprotein r= 0.712, p 0.001 with weak correlation with statistical significance as per Spearmans correlation. Area under ROC curve for High sensitive C-Reactive Protein indicated it as a positive biomarker for cardiovascular risk assessment.

CONCLUSIONS

Our findings shows that sch patients are more at risk of cvd and hs-crp contributes as a significant marker, thus requiring timely intervention. Lipid indices and AIP must be determined even in patients with a normal lipid profile to improve atherogenic risk.

摘要

背景

本研究旨在探讨亚临床甲状腺功能减退症与高敏 C 反应蛋白和血脂谱的相关性，这些因素可能导致心血管疾病的发生。

方法

本研究为为期六个月的基于医院的对比性横断面研究。共纳入 71 例亚临床甲状腺功能减退症患者和 37 例健康对照者。测定甲状腺激素、血脂谱、高敏 C 反应蛋白，并用血脂变量计算血脂指数。采用学生 t 检验比较均值，采用斯皮尔曼相关分析确定变量之间的相关性。采用 ROC 曲线分析评估检验的诊断价值。

结果

在 71 例病例和 37 例对照中，大多数为女性（病例组 71.8%，对照组 83.8%）。病例组和对照组高敏 C 反应蛋白、血浆致动脉粥样硬化指数、脂蛋白综合指数和非高密度脂蛋白胆固醇的均值差异具有统计学意义。促甲状腺激素与高敏 C 反应蛋白之间呈正相关（r=0.492，p<0.001），血浆致动脉粥样硬化指数与促甲状腺激素之间呈正相关（r=0.430，p<0.001），脂蛋白综合指数与促甲状腺激素之间呈正相关（r=0.269，p=0.005），促甲状腺激素与非高密度脂蛋白胆固醇之间呈正相关（r=0.308，p=0.001），致动脉粥样硬化指数与低密度脂蛋白之间呈正相关（r=0.712，p<0.001），这些相关性均具有统计学意义。ROC 曲线下面积分析表明，高敏 C 反应蛋白是心血管风险评估的阳性生物标志物。