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哥伦比亚一家移植中心活体肾供者的肾功能结局

Renal function outcomes in living kidney donors in a transplant center in Colombia.

作者信息

Torres Rodolfo, Reina Maricely, Montero Camilo, Tunjano Andres, Andrade David, Mancera Valeria, Amaya Maria, Arias Lizeth, Castellanos Laura, Vanegas Valentina

机构信息

Renal Transplant Service, Clínica Universitaria Colombia Keralty, Bogota, Colombia.

Translational Research Group, Fundación Universitaria Sánitas, Bogota, Colombia.

出版信息

SAGE Open Med. 2024 Nov 21;12:20503121241298139. doi: 10.1177/20503121241298139. eCollection 2024.

Abstract

INTRODUCTION

Living kidney donation is currently low in Colombia, and this is associated with the lack of knowledge of the risks and renal function outcomes of potential donors; there are no studies that evaluate these outcomes. The objective of this study is to evaluate the outcomes of renal function, the incidence of metabolic diseases, arterial hypertension, as well as the finding of albuminuria and/or proteinuria in living kidney donors with a 2-year follow-up post donation.

METHODS

Observational study in living kidney donor patients, in which renal function outcomes were evaluated between the predonation period and up to 24 months postdonation.

RESULTS

Ninety-one patients were included, with a median predonation glomerular filtration rate of 98 ml/min/1.73 m, interquartile range (90.5-109), and 24-month postdonation of 66.3 ml/min/1.73 m interquartile range (57.9-75). A total of 60.26% of the population was in stage 2 at the end of follow-up and no patient had a glomerular filtration rate less than 30 ml/min/1.73 m or required renal support therapy.

CONCLUSION

A living donor evaluation process based on risk factor stratification and adequate assessment of renal function was found to generate safe renal function outcomes both in the perioperative period and in medium- and long-term follow-up.

摘要

引言

目前,哥伦比亚活体肾捐赠率较低,这与潜在捐赠者对风险及肾功能结果缺乏了解有关;尚无研究评估这些结果。本研究的目的是评估活体肾捐赠者在捐赠后2年随访期内的肾功能结果、代谢性疾病发病率、动脉高血压情况以及白蛋白尿和/或蛋白尿的发现情况。

方法

对活体肾捐赠者患者进行观察性研究,评估捐赠前至捐赠后24个月的肾功能结果。

结果

纳入91例患者,捐赠前肾小球滤过率中位数为98 ml/min/1.73m²,四分位间距(90.5 - 109),捐赠后24个月为66.3 ml/min/1.73m²,四分位间距(57.9 - 75)。随访结束时,共有60.26%的人群处于2期,且无患者肾小球滤过率低于30 ml/min/1.73m²或需要肾脏支持治疗。

结论

基于风险因素分层和对肾功能进行充分评估的活体捐赠者评估过程,在围手术期以及中长期随访中均产生了安全的肾功能结果。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c0cf/11580066/4c36967d2d44/10.1177_20503121241298139-fig1.jpg

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