柚子果实提取物可减轻肥胖患者外周血中的氧化损伤。
Pummelo fruit extract () reduces oxidative damage in peripheral blood of obese patients.
作者信息
Nunes Vinícius Tejada, Gonçalves Itamar Luís, Schmitt Elizandra Gomes, Schreiner Gênifer Erminda, Dos Santos Laura Smolski, de Moura Sarmento Silvia Muller, Pereira Camila Berny, da Costa Escobar Piccoli Jacqueline, Manfredini Vanusa, Denardin Cristiane Casagrande
机构信息
Programa de Pós-graduação em Bioquímica, Universidade Federal do Pampa, Campus Uruguaiana, Uruguaiana, BR 472, km 585, Rio Grande do Sul, 97508-000, Brazil.
Universidade Regional Integrada Alto Uruguai e Missões, - Erechim, Sete de Setembro Avenue, 1621, Erechim, Rio Grande do Sul, 99709-910, Brazil.
出版信息
Toxicol Res (Camb). 2024 Nov 22;13(6):tfae192. doi: 10.1093/toxres/tfae192. eCollection 2024 Dec.
OBJECTIVES
To verify the level of oxidation of biomolecules in the peripheral blood of obese patients before and after incubation with the pummelo pulp extract at 25 mg/mL.
METHODS
This investigation included 241 individuals, distributed across the following groups: control (n = 69; 30 men and 39 women); pre-obesity (n = 78; 29 men and 49 women); level I obesity (n = 62; 20 men and 42 women); and level II or III obesity (n = 32; 11 men and 21 women).
RESULTS
TBARS and MN levels were significantly altered by incubation with pummelo extract in both genders and in all the groups according to their obesity level. Another alteration in the antioxidant profile of the samples was a significant increase in vitamin C levels observed after incubation with pummelo extract in all experimental groups.
CONCLUSIONS
The aqueous extract of pummelo pulp showed biological activity against the oxidation of biomolecules, suggesting that its bioactive compounds may bring health benefits of obese patients.
目的
验证肥胖患者外周血中的生物分子在与浓度为25mg/mL的柚子果肉提取物孵育前后的氧化水平。
方法
本研究纳入了241名个体，分布于以下几组：对照组（n = 69；30名男性和39名女性）；肥胖前期（n = 78；29名男性和49名女性）；I级肥胖（n = 62；20名男性和42名女性）；以及II级或III级肥胖（n = 32；11名男性和21名女性）。
结果
根据肥胖程度，在所有组别的男女中，与柚子提取物孵育后，丙二醛（TBARS）和甲萘醌（MN）水平均发生了显著变化。样本抗氧化谱的另一个变化是，在所有实验组中，与柚子提取物孵育后观察到维生素C水平显著升高。
结论
柚子果肉的水提取物对生物分子的氧化具有生物活性，表明其生物活性化合物可能对肥胖患者有益健康。
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