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本文引用的文献

1
The formation of aggregated chromatin/chromosomes in mouse oocytes treated with high concentration of IBMX as a model for a chromosome transfer in human.高浓度 IBMX 处理的小鼠卵母细胞中聚集染色质/染色体的形成，作为人类染色体转移的模型。
Syst Biol Reprod Med. 2024 Dec;70(1):195-203. doi: 10.1080/19396368.2024.2368116. Epub 2024 Jul 7.
2
Mechanism of chromosomal mosaicism in preimplantation embryos and its effect on embryo development.胚胎植入前染色体嵌合体的形成机制及其对胚胎发育的影响。
J Assist Reprod Genet. 2024 May;41(5):1127-1141. doi: 10.1007/s10815-024-03048-2. Epub 2024 Feb 22.
3
Nuclear Morphological Abnormalities in Cancer: A Search for Unifying Mechanisms.癌症中的核形态异常：寻求统一机制。
Results Probl Cell Differ. 2022;70:443-467. doi: 10.1007/978-3-031-06573-6_16.
4
Differential contribution of nuclear size scaling mechanisms between Xenopus species.不同爪蟾物种中核大小缩放机制的差异贡献。
Dev Growth Differ. 2022 Dec;64(9):501-507. doi: 10.1111/dgd.12819. Epub 2022 Nov 5.
5
Aneuploidy in mammalian oocytes and the impact of maternal ageing.哺乳动物卵母细胞中的非整倍体及母体老化的影响。
Nat Rev Mol Cell Biol. 2023 Jan;24(1):27-44. doi: 10.1038/s41580-022-00517-3. Epub 2022 Sep 6.
6
The Nuclear-to-Cytoplasmic Ratio: Coupling DNA Content to Cell Size, Cell Cycle, and Biosynthetic Capacity.核质比：将 DNA 含量与细胞大小、细胞周期和生物合成能力相偶联。
Annu Rev Genet. 2022 Nov 30;56:165-185. doi: 10.1146/annurev-genet-080320-030537. Epub 2022 Aug 17.
7
Control of nuclear size by osmotic forces in .渗透压控制细胞核大小。
Elife. 2022 Jul 20;11:e76075. doi: 10.7554/eLife.76075.
8
Nuclear-to-cytoplasmic ratios of 1PN and 2PN zygotes after fertilization of mouse oocytes.受精后小鼠卵母细胞 1PN 和 2PN 胚胎的核质比。
Zygote. 2022 Feb;30(1):120-124. doi: 10.1017/S096719942100040X. Epub 2021 Jun 28.
9
DNA content contributes to nuclear size control in .DNA 含量有助于控制 的核大小。
Mol Biol Cell. 2020 Nov 15;31(24):2703-2717. doi: 10.1091/mbc.E20-02-0113. Epub 2020 Sep 30.
10
Noninvasive embryo selection: kinetic analysis of female and male pronuclear development to predict embryo quality and potential to produce live birth.非侵入性胚胎选择：对雌性和雄性原核发育的动力学分析，以预测胚胎质量和产生活产的潜力。
Fertil Steril. 2019 Nov;112(5):874-881. doi: 10.1016/j.fertnstert.2019.07.015. Epub 2019 Oct 23.

小鼠合子期雌原核/细胞质比率与染色体数目之间的相关性：对辅助生殖技术中染色体非整倍体评估的意义

Correlation between female pronuclear/cytoplasmic ratio and number of chromosomes in mouse zygotic stage: implications for aneuploidy assessment in ART.

作者信息

Xiao Wei, Akao Sakura, Otsuki Junko

机构信息

Graduate School of Environmental, Life, Natural Science and Technology, Okayama University, 1-1-1 Tsushimanaka, Kita, Okayama, 700-8530, Japan.

Faculty of Agriculture, Okayama University, 1-1-1 Tsushimanaka, Kita, Okayama, 700-8530, Japan.

出版信息

J Assist Reprod Genet. 2025 Jan;42(1):85-95. doi: 10.1007/s10815-024-03312-5. Epub 2024 Nov 25.

DOI:10.1007/s10815-024-03312-5
PMID:39585518
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11805731/
Abstract

PURPOSE

The objective of this study was to investigate the correlation between the pronuclear/cytoplasmic (PN/C) ratio and the number of chromosomes in mouse zygotes to understand the implications of pronuclear size regulation in early embryonic development.

METHODS

A combination of enucleation and aggregated chromosomes/chromatin (AC) transfer was utilized to create oocytes with varying numbers of chromosomes. Time-lapse imaging and immunofluorescence staining were employed to analyze pronuclear dynamics and chromosomal configurations.

RESULTS

Higher chromosome numbers correspond to a larger PN/C ratio. Oocytes with a higher number of chromosomes exhibited larger pronuclei.

CONCLUSION

The study underscores the complexity of pronuclear size regulation and its correlation with the number of chromosomes. The findings suggest potential applications in ART, where assessing the PN/C ratio could serve as a biomarker for zygote quality and aneuploidy.

摘要

目的

本研究的目的是调查小鼠受精卵中原核/细胞质（PN/C）比率与染色体数量之间的相关性，以了解原核大小调控在早期胚胎发育中的意义。

方法

采用去核与聚集染色体/染色质（AC）转移相结合的方法，创建具有不同染色体数量的卵母细胞。利用延时成像和免疫荧光染色分析原核动态和染色体构型。

结果

染色体数量越多，PN/C比率越大。染色体数量较多的卵母细胞表现出更大的原核。

结论

该研究强调了原核大小调控的复杂性及其与染色体数量的相关性。研究结果表明，在辅助生殖技术（ART）中可能具有潜在应用，评估PN/C比率可作为受精卵质量和非整倍体的生物标志物。