Balhotra Kimen S, Sibai Baha M
Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, University of Texas Health Science Center at Houston, Houston, TX.
Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, University of Texas Health Science Center at Houston, Houston, TX.
Am J Obstet Gynecol MFM. 2025 Mar;7(1S):101568. doi: 10.1016/j.ajogmf.2024.101568. Epub 2024 Nov 24.
Research conducted over the past few decades has shown that low-dose aspirin can effectively reduce the risk of developing preeclampsia. Consequently, numerous prominent organizations have adopted the recommendation to use low-dose aspirin during pregnancy to prevent preeclampsia. However, the optimal dosage of low-dose aspirin (81mg versus 162mg) remains a subject of debate. Currently, there is insufficient high-quality data to justify the use of a higher dosage of low-dose aspirin. In this review, we review the existing evidence that supports the continued use of 81mg of aspirin over a higher dose and emphasize the need for high-quality research to alter current recommendations.
过去几十年进行的研究表明，低剂量阿司匹林可有效降低患先兆子痫的风险。因此，许多知名组织都采纳了在孕期使用低剂量阿司匹林预防先兆子痫的建议。然而，低剂量阿司匹林的最佳剂量（81毫克与162毫克）仍是一个有争议的话题。目前，尚无足够的高质量数据证明使用更高剂量的低剂量阿司匹林是合理的。在本综述中，我们回顾了支持继续使用81毫克阿司匹林而非更高剂量的现有证据，并强调需要高质量研究来改变当前的建议。
