Myology Lab, Institute of Biomedical Problems of the Russian Academy of Sciences, 123007 Moscow, Russia.
Int J Mol Sci. 2024 Nov 20;25(22):12462. doi: 10.3390/ijms252212462.
In most mammals, postural soleus muscles are involved in the maintenance of the stability of the body in the gravitational field of Earth. It is well established that immediately after a laboratory rat is exposed to conditions of weightlessness (parabolic flight) or simulated microgravity (hindlimb suspension/unloading), a sharp decrease in soleus muscle electrical activity occurs. However, starting from the 3rd day of mechanical unloading, soleus muscle electrical activity begins to increase and reaches baseline levels approximately by the 14th day of hindlimb suspension. This phenomenon, observed in the course of rat hindlimb suspension, was named the "spontaneous electrical activity of postural muscle". The present review discusses spinal mechanisms underlying the development of such spontaneous activity of rat soleus muscle and the effect of this activity on intracellular signaling in rat soleus muscle during mechanical unloading.
在大多数哺乳动物中，姿势性比目鱼肌参与维持身体在地球引力场中的稳定性。已经证实，在实验室大鼠暴露于失重（抛物线飞行）或模拟微重力（后肢悬吊/卸载）条件后，比目鱼肌的电活动会急剧下降。然而，从机械卸载的第 3 天开始，比目鱼肌的电活动开始增加，并在大约第 14 天的后肢悬吊后达到基线水平。在大鼠后肢悬吊过程中观察到的这种现象被称为“姿势肌的自发性电活动”。本综述讨论了大鼠比目鱼肌自发性活动发展的脊髓机制，以及这种活动对机械卸载过程中大鼠比目鱼肌细胞内信号转导的影响。
