Doctoral Program of Medical Science, Faculty of Medicine, Universitas Airlangga, Surabaya 60132, Indonesia.
Department of Clinical Pathology, Laboratory and Blood Bank, National Brain Center Hospital Prof. Dr. dr. Mahar Mardjono, Jakarta 13630, Indonesia.
Medicina (Kaunas). 2024 Oct 25;60(11):1755. doi: 10.3390/medicina60111755.
: The management of ischemic stroke involves care that is integrated and comprehensive, including the prevention of infection complications. This study aimed to investigate the prevalence and profile of bacterial infections after acute ischemic stroke both before and during the coronavirus disease 2019 (COVID-19) pandemic. : A retrospective cross-sectional study examined the medical records of hospitalized acute ischemic stroke patients who had microbiological cultures taken at the National Brain Center Hospital Prof. Dr. dr. Mahar Mardjono, Jakarta, Indonesia, from 1 January 2018 to 31 December 2021. The percentage of positive bacterial growth in the microbiological cultures was used to determine the prevalence of bacterial infection after acute ischemic stroke. : A total of 519 patients met the study criteria, including 48 and 471 patients with infections before and during the COVID-19 pandemic. The prevalence of bacterial infection after acute ischemic stroke was 17.9%. There were significant differences in the prevalence of bacterial infection after acute ischemic stroke before and during the COVID-19 pandemic (87.5% vs. 10.8%). sp. and sp. were the most frequently observed. The risk factors that influenced bacterial infection after acute ischemic stroke were intensive care stay (OR 0.22; 95%CI 0.13-0.39, -value < 0.001), sepsis (OR 1.99; 95%CI 1.12-3.53, -value = 0.019), COVID-19 infection (OR 4.81; 95%CI 2.64-8.76, -value < 0.001), the use of steroids (OR 0.31; 95%CI 0.14-0.67, -value = 0.003), and the use of TPN (OR 0.34; 95%CI 0.13-0.86, -value = 0.022). : Following the start of the COVID-19 pandemic, there was a decrease in the prevalence of bacterial infections after AIS. Patients with bacterial infections had different profiles before and during the COVID-19 pandemic.
缺血性脑卒中的管理包括综合和全面的护理，包括预防感染并发症。本研究旨在调查 2019 年冠状病毒病（COVID-19）大流行前后急性缺血性脑卒中患者发生细菌感染的患病率和特征。
这是一项回顾性横断面研究，对在印度尼西亚雅加达 Mahar Mardjono 教授博士医院国家脑中心住院的急性缺血性脑卒中患者的病历进行了检查，这些患者的微生物培养物是在 2018 年 1 月 1 日至 2021 年 12 月 31 日期间采集的。微生物培养物中阳性细菌生长的百分比用于确定急性缺血性脑卒中后细菌感染的患病率。
共有 519 名符合研究标准的患者，其中 48 名和 471 名患者分别在 COVID-19 大流行前和期间发生感染。急性缺血性脑卒中后细菌感染的患病率为 17.9%。COVID-19 大流行前后急性缺血性脑卒中后细菌感染的患病率存在显著差异（87.5%比 10.8%）。 sp. 和 sp. 是最常观察到的。影响急性缺血性脑卒中后细菌感染的危险因素包括重症监护停留（OR 0.22；95%CI 0.13-0.39，-值<0.001）、败血症（OR 1.99；95%CI 1.12-3.53，-值=0.019）、COVID-19 感染（OR 4.81；95%CI 2.64-8.76，-值<0.001）、使用类固醇（OR 0.31；95%CI 0.14-0.67，-值=0.003）和使用 TPN（OR 0.34；95%CI 0.13-0.86，-值=0.022）。
自 COVID-19 大流行开始以来，急性缺血性脑卒中后细菌感染的患病率有所下降。COVID-19 大流行前后细菌感染患者的特征不同。
