使用连续血糖监测检测囊性纤维化患儿血糖异常的可行性
Feasibility of Using Continuous Glucose Monitoring to Detect Glycemic Abnormalities in Children with Cystic Fibrosis.
作者信息
Leonard Amanda, Judware Isabel R, Vanscoy Lori L, Paranjape Shruti M, Peeler Donna, Wu Malinda, Blackman Scott M, Mogayzel Peter J
机构信息
Division of Pediatric Nutrition, Johns Hopkins Hospital, Baltimore, Maryland, USA.
Eudowood Division of Pediatric Respiratory Sciences, Johns Hopkins School of Medicine, Baltimore, Maryland, USA.
出版信息
Horm Res Paediatr. 2024 Nov 27:1-6. doi: 10.1159/000542786.
INTRODUCTION
Cystic fibrosis-related diabetes (CFRD) is linked to worsening pulmonary function and increased mortality in people with cystic fibrosis (CF). Because of this correlation, early recognition of CFRD is important. Current recommendations for detecting glucose abnormalities using an oral glucose tolerance test (OGTT) can be difficult to achieve in a busy clinical setting.
METHODS
We trialed a 10-day continuous glucose monitoring (CGM) (Dexcom G6Pro) session in patients seen in our pediatric CF clinic that could not do an OGTT (reasons include emesis with OGTT or fear of needles) or that had an abnormal OGTT (to gather additional data to make treatment decisions).
RESULTS
Of the 36 sensors placed, 34 (94%) were returned. Devices were worn for a median of 10 days (range 4-10 days). Of the 34 CGMs returned, 20 (59%) met the criterion for referral to a pediatric endocrinologist.
CONCLUSION
CGM placement is feasible in a busy CF clinic to detect glucose abnormalities in children.
引言
囊性纤维化相关糖尿病（CFRD）与囊性纤维化（CF）患者肺功能恶化及死亡率增加有关。鉴于这种相关性，早期识别CFRD很重要。在繁忙的临床环境中，按照当前使用口服葡萄糖耐量试验（OGTT）检测血糖异常的建议可能难以实现。
方法
我们对在我们儿科CF诊所就诊的患者进行了为期10天的持续葡萄糖监测（CGM）（德康G6 Pro），这些患者无法进行OGTT（原因包括OGTT时呕吐或害怕打针）或OGTT结果异常（以收集更多数据用于制定治疗决策）。
结果
在放置的36个传感器中，34个（94%）被退回。设备佩戴时间中位数为10天（范围4 - 10天）。在退回的34次CGM监测中，20次（59%）符合转诊至儿科内分泌科医生的标准。
结论
在繁忙的CF诊所中放置CGM以检测儿童血糖异常是可行的。
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