Beniz Luiz A F, Jammal Alessandro A, da Costa Douglas R, Mariottoni Eduardo B, Swaminathan Swarup S, Medeiros Felipe A
Bascom Palmer Eye Institute, University of Miami.
Department of Ophthalmology and Visual Sciences, Paulista School of Medicine, Federal University of São Paulo.
Res Sq. 2024 Nov 13:rs.3.rs-5040415. doi: 10.21203/rs.3.rs-5040415/v1.
This study assessed the impact of race and ethnicity on longitudinal test variability and time to detect glaucoma progression using standard automated perimetry (SAP) and optical coherence tomography (OCT). The sample consisted of 47,003 SAP tests from 5,402 eyes and 25,480 OCT tests from 4,125 eyes, with 20% of participants self-identifying as Black or African American and 80% as White; 29% as Hispanic or Latino and 71% as Not Hispanic or Latino. Variability was measured using standard deviations of residuals from linear regression models for SAP mean deviation (MD) and OCT retinal nerve fiber layer (RNFL) thickness over time. Results showed significantly greater SAP variability in Black or African American (1.80±1.30dB) compared to White participants (1.56±1.21dB; P<0.001) and in Hispanic or Latino (1.81±1.46dB) compared to Not Hispanic or Latino individuals (1.52±1.10dB; P<0.001). OCT variability was higher in Black or African American (2.3±1.5μm) compared to White (2.1±1.3μm; P<0.001) and in Not Hispanic or Latino (2.2±1.3μm) compared to Hispanic or Latino (2.1±1.2μm; P=0.029). Increased SAP variability delayed progression detection, while OCT showed minimal differences. These findings suggest that higher perimetric variability in Black or African American and Hispanic or Latino may affect glaucoma progression detection using SAP.
本研究评估了种族和族裔对使用标准自动视野计（SAP）和光学相干断层扫描（OCT）进行纵向测试变异性以及检测青光眼进展时间的影响。样本包括来自5402只眼睛的47003次SAP测试和来自4125只眼睛的25480次OCT测试，20%的参与者自我认定为黑人或非裔美国人，80%为白人；29%为西班牙裔或拉丁裔，71%为非西班牙裔或拉丁裔。使用线性回归模型中SAP平均偏差（MD）和OCT视网膜神经纤维层（RNFL）厚度随时间变化的残差标准差来测量变异性。结果显示，与白人参与者（1.56±1.21dB；P<0.001）相比，黑人或非裔美国人的SAP变异性显著更大（1.80±1.30dB），与非西班牙裔或拉丁裔个体（1.52±1.10dB；P<0.001）相比，西班牙裔或拉丁裔的变异性更大（1.81±1.46dB）。与白人（2.1±1.3μm；P<0.001）相比，黑人或非裔美国人的OCT变异性更高（2.3±1.5μm），与西班牙裔或拉丁裔（2.1±1.2μm；P=0.029）相比，非西班牙裔或拉丁裔的变异性更高（2.2±1.3μm）。SAP变异性增加会延迟进展检测，而OCT显示出最小差异。这些发现表明，黑人或非裔美国人以及西班牙裔或拉丁裔较高的视野变异性可能会影响使用SAP检测青光眼进展。
