昼夜节律重新调整与情绪低落：一项系统综述。
Circadian realignment and depressed mood: A systematic review.
作者信息
Wescott Delainey L, Hasler Brant P, Foust Jill E, Roecklein Kathryn A
机构信息
Department of Psychology, University of Pittsburgh, Pittsburgh, PA, USA.
Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
出版信息
Sleep Med Rev. 2025 Feb;79:102022. doi: 10.1016/j.smrv.2024.102022. Epub 2024 Nov 12.
Chronotherapeutic interventions aimed at realigning the circadian system can improve depression. This systematic review evaluated the current evidence for circadian realignment as an antidepressant mechanism. A comprehensive search was conducted in studies that implemented a chronotherapeutic intervention in samples with depression and/or delayed sleep/circadian timing using PubMed, EMBASE, Cochrane Central Register of Controlled Trials (Wiley), Europe PMC, and PsycINFO. The Downs and Black checklist was used to evaluate study quality. There were 58 studies included, of which 23 studies reported the association between realignment and depression. Circadian realignment was associated with improved depression in studies that included participants with baseline delays and elevated depression. Randomized clinical trials measuring circadian phase markers are needed to further elucidate circadian realignment as an antidepressant mechanism.
旨在重新调整昼夜节律系统的时间治疗干预措施可以改善抑郁症。本系统评价评估了将昼夜节律重新调整作为一种抗抑郁机制的现有证据。通过PubMed、EMBASE、Cochrane对照试验中央注册库（Wiley）、欧洲生物医学信息学图书馆（Europe PMC）和PsycINFO，对在患有抑郁症和/或睡眠/昼夜节律延迟的样本中实施时间治疗干预的研究进行了全面检索。采用唐斯和布莱克清单来评估研究质量。共纳入58项研究，其中23项研究报告了重新调整与抑郁症之间的关联。在纳入基线延迟和抑郁症程度较高参与者的研究中，昼夜节律重新调整与抑郁症改善相关。需要进行测量昼夜节律相位标志物的随机临床试验，以进一步阐明昼夜节律重新调整作为一种抗抑郁机制。
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