肠肽酶在蛋白质消化中的作用及其在人胎儿小肠中的发育。
The role of enteropeptidase in the digestion of protein and its development in human fetal small intestine.
作者信息
Antonowicz I
出版信息
Ciba Found Symp. 1979(70):169-87. doi: 10.1002/9780470720530.ch10.
PMID:396133
Abstract
Enteropeptidase converts trypsinogen into active trypsin, which not only hydrolyses some peptide bonds of food proteins but also activates a number of pancreatic zymogens. For this reason enteropeptidase is a key enzyme in the digestion of dietary proteins and its absence may result in gross protein malabsorption.
摘要
肠肽酶将胰蛋白酶原转化为活性胰蛋白酶，胰蛋白酶不仅能水解食物蛋白质的一些肽键，还能激活多种胰酶原。因此，肠肽酶是膳食蛋白质消化中的关键酶，缺乏肠肽酶可能导致严重的蛋白质吸收不良。
相似文献
1
The role of enteropeptidase in the digestion of protein and its development in human fetal small intestine.肠肽酶在蛋白质消化中的作用及其在人胎儿小肠中的发育。
Ciba Found Symp. 1979(70):169-87. doi: 10.1002/9780470720530.ch10.
2
Structural basis for the specific activation of human enteropeptidase.人肠肽酶特异性激活的结构基础。
J Biol Chem. 1978 Apr 25;253(8):2737-42.
3
Specificity studies on enteropeptidase substrates related to the N-terminus of trypsinogen.与胰蛋白酶原N端相关的肠肽酶底物特异性研究。
Biochem J. 1987 Feb 1;241(3):721-7. doi: 10.1042/bj2410721.
4
Enteropeptidase, a type II transmembrane serine protease.肠肽酶，一种II型跨膜丝氨酸蛋白酶。
Front Biosci (Elite Ed). 2009 Jun 1;1(1):242-9. doi: 10.2741/E23.
5
Hydrolysis of proteins and proteolytic activity.蛋白质的水解及蛋白水解活性。
J Pediatr Gastroenterol Nutr. 1983;2 Suppl 1:S252-9. doi: 10.1097/00005176-198300201-00038.
6
Bovine proenteropeptidase is activated by trypsin, and the specificity of enteropeptidase depends on the heavy chain.牛前肠肽酶由胰蛋白酶激活，肠肽酶的特异性取决于重链。
J Biol Chem. 1997 Dec 12;272(50):31293-300. doi: 10.1074/jbc.272.50.31293.
7
Pancreaticobiliary factors in the modulation of small intestinal enterokinase in the rat.大鼠小肠肠激酶调节中的胰胆因素
Am J Physiol. 1986 Jan;250(1 Pt 1):G103-8. doi: 10.1152/ajpgi.1986.250.1.G103.
8
The application of a new synthetic substrate to the determination of enteropeptidase in rat small intestine and human intestinal biopsies.一种新型合成底物在大鼠小肠和人肠道活检组织中肠肽酶测定中的应用。
Clin Chim Acta. 1980 Feb 14;101(1):69-76. doi: 10.1016/0009-8981(80)90057-1.
9
Histochemical demonstration of enteropeptidase activity. New method with a synthetic substrate and its comparison with the trypsinogen procedure.肠肽酶活性的组织化学证明。一种使用合成底物的新方法及其与胰蛋白酶原检测方法的比较。
Histochemistry. 1983;78(2):251-70. doi: 10.1007/BF00489503.
10
The tetra-aspartate motif in the activation peptide of human cationic trypsinogen is essential for autoactivation control but not for enteropeptidase recognition.人阳离子胰蛋白酶原激活肽中的四聚天冬氨酸基序对于自身激活控制至关重要，但对于肠肽酶识别并非如此。
J Biol Chem. 2005 Aug 19;280(33):29645-52. doi: 10.1074/jbc.M505661200. Epub 2005 Jun 21.
引用本文的文献
1
Methods for improving meat protein digestibility in older adults.提高老年人肉类蛋白质消化率的方法。
J Anim Sci Technol. 2023 Jan;65(1):32-56. doi: 10.5187/jast.2023.e6. Epub 2023 Jan 31.
2
Effect of the vitamin B12-binding protein haptocorrin present in human milk on a panel of commensal and pathogenic bacteria.人乳中存在的维生素B12结合蛋白运钴胺素对一组共生菌和病原菌的影响。
BMC Res Notes. 2011 Jun 21;4:208. doi: 10.1186/1756-0500-4-208.
3
Histochemical demonstration of enteropeptidase activity. New method with a synthetic substrate and its comparison with the trypsinogen procedure.肠肽酶活性的组织化学证明。一种使用合成底物的新方法及其与胰蛋白酶原检测方法的比较。
Histochemistry. 1983;78(2):251-70. doi: 10.1007/BF00489503.
Zotero 插件