Feng Tong, Li Qingyuan, Chen Yingyi, Duan Ran
The Second School of Clinical Medicine, Southern Medical University, Guangzhou, China.
School of Clinical Medicine, Chengdu Medical College, Chengdu, Sichuan, China.
Eur Arch Otorhinolaryngol. 2024 Nov 29. doi: 10.1007/s00405-024-09089-8.
Obstructive Sleep Apnea (OSA) is a prevalent sleep disorder linked to increased risks of cardiovascular and metabolic disorders, significantly raising overall mortality rates. This study explores the associations between OSA and mortality in adults with and without Metabolic Syndrome (MetS) using data from the National Health and Nutrition Examination Survey (NHANES).
Data from NHANES (2005-2008) were analyzed, including 11,759 participants. OSA and MetS were identified based on survey responses and standard clinical criteria. Cox proportional hazards regression models were used to assess the relationship between OSA and mortality, adjusting for covariates. OSA was associated with significantly higher all-cause and cardiovascular mortality in the general population. In individuals without MetS, OSA was linked to higher all-cause and cardiovascular mortality. However, in individuals with MetS, OSA did not significantly affect mortality rates after adjusting for covariates.
OSA increases the risk of all-cause and cardiovascular mortality in individuals without MetS, emphasizing the need for early identification and management, particularly in those without metabolic comorbidities. In contrast, the impact of OSA on mortality in individuals with MetS may be mitigated by medical monitoring and treatment. These findings highlight the importance of individualized clinical strategies and call for further research to explore the underlying mechanisms of OSA-MetS interactions.
阻塞性睡眠呼吸暂停（OSA）是一种常见的睡眠障碍，与心血管和代谢紊乱风险增加相关，显著提高了总体死亡率。本研究利用美国国家健康与营养检查调查（NHANES）的数据，探讨患有和未患有代谢综合征（MetS）的成年人中OSA与死亡率之间的关联。
对NHANES（2005 - 2008年）的数据进行了分析，包括11759名参与者。根据调查回复和标准临床标准确定OSA和MetS。使用Cox比例风险回归模型评估OSA与死亡率之间的关系，并对协变量进行调整。在一般人群中，OSA与全因死亡率和心血管死亡率显著升高相关。在没有MetS的个体中，OSA与较高的全因死亡率和心血管死亡率相关。然而，在患有MetS的个体中，调整协变量后，OSA对死亡率没有显著影响。
OSA增加了没有MetS的个体的全因死亡率和心血管死亡率风险强调了早期识别和管理的必要性，特别是在那些没有代谢合并症的个体中。相比之下，医疗监测和治疗可能会减轻OSA对患有MetS的个体死亡率的影响。这些发现突出了个体化临床策略的重要性，并呼吁进一步研究以探索OSA - MetS相互作用的潜在机制。
