Tauveron-Jalenques Urbain, Sarr Khadim, Guièze Romain, Giordano Chloé, Rouanet Jacques, Hayette Sandrine, Chevenet Carole, Heiblig Maël, Ravinet Aurélie
Cellular Therapy and Clinical Haematology Department, Clermont-Ferrand University Hospital, 1 Rue Lucie et Raymond Aubrac, Clermont-Ferrand, 63100, France.
EA7453 (CHELTER), Clermont Auvergne University, Clermont-Ferrand, France.
Ann Hematol. 2024 Dec;103(12):5985-5988. doi: 10.1007/s00277-024-06127-7. Epub 2024 Nov 30.
Menin-KMT2A inhibitors (MENi) are a novel class of small-molecule inhibitors in development in KMT2Ar and NPM1 acute myeloid leukaemias (AML) and a notorious cause of differentiation syndrome (DS). A 71 years old woman received the MENi revumenib (REV) for relapsed/refractory NPM1 AML. After 2 weeks of treatment, she developed fever and a violaceous inflammatory cutaneous lesion of the right cheek, revealing REV induced pyoderma gangrenosum (PG)-like neutrophilic dermatosis (ND). Isolated reports of all-trans retinoic acid induced DS-related ND have been published. However, to our knowledge, this is the first report ever of MENi induced PG-like ND and cutaneous involvement of DS. This report highlights the fact that ND such as PG, as a manifestation of DS, are a possibly severe adverse effect of MENi.
Menin-KMT2A抑制剂（MENi）是一类正在开发用于治疗KMT2Ar和NPM1急性髓系白血病（AML）的新型小分子抑制剂，也是分化综合征（DS）的一个臭名昭著的病因。一名71岁女性因复发/难治性NPM1 AML接受了MENi瑞武单抗（REV）治疗。治疗2周后，她出现发热和右脸颊紫罗兰色炎症性皮肤病变，显示为REV诱导的坏疽性脓皮病（PG）样嗜中性皮病（ND）。全反式维甲酸诱导的与DS相关的ND已有孤立报道。然而，据我们所知，这是首例关于MENi诱导的PG样ND和DS皮肤受累的报告。本报告强调了这样一个事实，即诸如PG之类的ND作为DS的一种表现，可能是MENi的一种严重不良反应。
