Guzman Roberto A, Ammons Jordan, Westberg Jerald R, Schmidt Andrew
Department of Orthopedic Surgery, University of Minnesota, Minneapolis, Minnesota; Department of Orthopaedic Surgery, Hennepin County Medical Center, Minneapolis, Minnesota.
Department of Orthopedic Surgery, University of Minnesota, Minneapolis, Minnesota.
J Arthroplasty. 2025 Jun;40(6):1478-1483. doi: 10.1016/j.arth.2024.11.040. Epub 2024 Nov 30.
Given the association between high opioid use and postoperative complications after total joint arthroplasty, it is important to prescribe opioids responsibly in the postoperative period. While many pain regimen protocols exist to try and limit opioid use, an optimal approach to narcotic prescription for arthroplasty patients is yet to be established. This study evaluated the effects of using an individualized opioid taper calculator for patients undergoing elective primary total hip arthroplasty (THA) and total knee arthroplasty (TKA). We hypothesized that using the calculator would lead to a decrease in the amount and variability of opioids prescribed postoperatively.
All primary THAs (117 precalculator and 105 postcalculator) and TKAs (172 precalculator and 139 postcalculator) meeting study inclusion and exclusion criteria were reviewed at a single academic hospital from January 2016 to December 2018 (precalculator) and January 2020 to December 2022 (postcalculator). The primary outcome measure was the quantity of opioids prescribed at discharge in morphine milligram equivalents between the two groups. Secondary measures included opioid refills, visual analog scale pain scores, and emergency department presentations or clinic calls due to pain. Statistical significance was defined as P <0.05.
Implementation of the opioid taper calculator resulted in a 40% decrease in the median morphine milligram equivalent prescribed at discharge for both THA (450 versus 270; P < 0.0001) and TKA (450 versus 270; P < 0.0001) patients, respectively. There was no significant difference within the THA or TKA cohorts when comparing visual analog scale pain scores (THA, 3 versus 4; P = 0.47; TKA; 5 versus 6, P = 0.26), and no increase in percentage of patients who had emergency department visits (THA, 5.98 versus 0.95%; P = 0.069; TKA, 6.40 versus 11.5%; P = 0.155) or calls to the clinic for pain (THA, 17.1 versus 24.8%; P = 0.186; TKA, 36.6 versus 37.4%; P = 0.906) between the precalculator and postcalculator groups.
Our findings support the use of a patient-specific opioid taper calculator to decrease the volume and variability of narcotics prescribed postoperatively for THA and TKA pain management. Our findings confirmed the general applicability and effectiveness of the opioid taper calculator outside of its institution of origin.
鉴于全关节置换术后高剂量阿片类药物使用与术后并发症之间的关联,在术后阶段合理开具阿片类药物至关重要。虽然存在许多疼痛治疗方案以尝试限制阿片类药物的使用,但针对关节置换术患者的最佳麻醉处方方法尚未确立。本研究评估了使用个体化阿片类药物减量计算器对接受择期初次全髋关节置换术(THA)和全膝关节置换术(TKA)患者的影响。我们假设使用该计算器将导致术后开具的阿片类药物数量减少且变异性降低。
对2016年1月至2018年12月(使用计算器前)和2020年1月至2022年12月(使用计算器后)在一家学术医院接受治疗、符合研究纳入和排除标准的所有初次THA(使用计算器前117例,使用计算器后105例)和TKA(使用计算器前172例,使用计算器后139例)患者进行了回顾性分析。主要结局指标是两组患者出院时以吗啡毫克当量计的阿片类药物处方量。次要指标包括阿片类药物的补充处方、视觉模拟量表疼痛评分以及因疼痛到急诊科就诊或致电诊所的情况。统计学显著性定义为P<0.05。
阿片类药物减量计算器的应用使THA患者(450 vs 270;P<0.0001)和TKA患者(450 vs 270;P<0.0001)出院时开具的吗啡毫克当量中位数分别减少了40%。在比较视觉模拟量表疼痛评分时,THA队列(3 vs 4;P = 0.47)和TKA队列(5 vs 6;P = 0.26)内无显著差异,并且在使用计算器前和使用计算器后的两组之间,因疼痛到急诊科就诊的患者百分比(THA,5.98% vs 0.95%;P = 0.069;TKA,6.40% vs 11.5%;P = 0.155)或致电诊所的患者百分比(THA,17.1% vs 24.8%;P = 0.186;TKA,36.6% vs 37.4%;P = 0.906)均未增加。
我们的研究结果支持使用针对患者的阿片类药物减量计算器,以减少THA和TKA疼痛管理术后开具的麻醉药品数量和变异性。我们的研究结果证实了阿片类药物减量计算器在其起源机构之外的普遍适用性和有效性。