Miranda William R, Jain C Charles, Connolly Heidi M, Van De Bruaene Alexander, Veldtman Gruschen R, Egbe Alexander C
Department of Cardiovascular Diseases, Mayo Clinic, Rochester, Minnesota, USA.
Division of Structural and Congenital Cardiology, Department of Cardiovascular Sciences, KU Leuven, Leuven, Belgium.
CJC Pediatr Congenit Heart Dis. 2024 Aug 2;3(5):225-228. doi: 10.1016/j.cjcpc.2024.07.003. eCollection 2024 Oct.
We hypothesized that phenotyping patients using a combination of resting peripheral venous pressure (PVP) and N-terminal pro-brain natriuretic peptide (NT-proBNP) would predict invasive Fontan haemodynamics. Accordingly, 35 adults with a history of Fontan palliation were categorized into 3 groups according to PVP and NT-proBNP values: normal, ↑NT-proBNP (≥300 pg/dL) or ↑PVP (≥15 mm Hg), and ↑PVP+↑NT-proBNP. Those in the normal values group universally had normal resting pulmonary artery wedge and Fontan pressures, with a single patient having abnormal exercise values; conversely, all patients in the ↑PVP+↑NT-proBNP group had increased resting Fontan or pulmonary artery wedge pressures, with those in the ↑NT-proBNP or ↑PVP group constituting an intermediate group.
我们假设，使用静息外周静脉压（PVP）和N末端脑钠肽前体（NT-proBNP）相结合的方法对患者进行表型分析，能够预测Fontan手术的有创血流动力学。因此，35名有Fontan姑息手术史的成年人根据PVP和NT-proBNP值被分为3组：正常组、NT-proBNP升高组（≥300 pg/dL）或PVP升高组（≥15 mmHg），以及PVP升高+NT-proBNP升高组。正常组患者静息肺动脉楔压和Fontan压力普遍正常，仅有1例患者运动时的值异常；相反，PVP升高+NT-proBNP升高组的所有患者静息Fontan或肺动脉楔压均升高，NT-proBNP升高组或PVP升高组的患者则构成中间组。
