外周静脉压和NT-前脑钠肽表型作为成人Fontan介入血流动力学的替代指标
Peripheral Venous Pressure And NT-proBNP Phenotypes as Surrogates for Invasive Fontan Haemodynamics in Adults.
作者信息
Miranda William R, Jain C Charles, Connolly Heidi M, Van De Bruaene Alexander, Veldtman Gruschen R, Egbe Alexander C
机构信息
Department of Cardiovascular Diseases, Mayo Clinic, Rochester, Minnesota, USA.
Division of Structural and Congenital Cardiology, Department of Cardiovascular Sciences, KU Leuven, Leuven, Belgium.
出版信息
CJC Pediatr Congenit Heart Dis. 2024 Aug 2;3(5):225-228. doi: 10.1016/j.cjcpc.2024.07.003. eCollection 2024 Oct.
We hypothesized that phenotyping patients using a combination of resting peripheral venous pressure (PVP) and N-terminal pro-brain natriuretic peptide (NT-proBNP) would predict invasive Fontan haemodynamics. Accordingly, 35 adults with a history of Fontan palliation were categorized into 3 groups according to PVP and NT-proBNP values: normal, ↑NT-proBNP (≥300 pg/dL) or ↑PVP (≥15 mm Hg), and ↑PVP+↑NT-proBNP. Those in the normal values group universally had normal resting pulmonary artery wedge and Fontan pressures, with a single patient having abnormal exercise values; conversely, all patients in the ↑PVP+↑NT-proBNP group had increased resting Fontan or pulmonary artery wedge pressures, with those in the ↑NT-proBNP or ↑PVP group constituting an intermediate group.
我们假设，使用静息外周静脉压（PVP）和N末端脑钠肽前体（NT-proBNP）相结合的方法对患者进行表型分析，能够预测Fontan手术的有创血流动力学。因此，35名有Fontan姑息手术史的成年人根据PVP和NT-proBNP值被分为3组：正常组、NT-proBNP升高组（≥300 pg/dL）或PVP升高组（≥15 mmHg），以及PVP升高+NT-proBNP升高组。正常组患者静息肺动脉楔压和Fontan压力普遍正常，仅有1例患者运动时的值异常；相反，PVP升高+NT-proBNP升高组的所有患者静息Fontan或肺动脉楔压均升高，NT-proBNP升高组或PVP升高组的患者则构成中间组。
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