Marumure Jerikias, Nyila Monde A
Department of Life and Consumer Sciences, College of Agriculture and Environmental Sciences, Science Campus, University of South Africa, Florida, Johannesburg 1710, South Africa.
J Trop Med. 2024 Nov 21;2024:1981991. doi: 10.1155/jotm/1981991. eCollection 2024.
Cholera, an intestinal infection caused by , poses a severe threat to public health, particularly in developing countries. This narrative review discusses drivers for cholera outbreaks, challenges and viable alternatives, in Zimbabwe. A literature search was conducted using electronic databases notably ScienceDirect, Google Scholar and PubMed, as well as thesis and conference papers. Evidence indicates that the epidemiology, as well as risk factors, includes (1) extreme droughts; (2) political meddling in health issues and water supply; (3) natural disasters; (4) migration; (5) problems with water and sanitation; and (6) the endemic nature of the causative agent as well as its development of drug resistance. Reliable supply of clean water and proper sanitation and hygiene as the main key to prevention is emphasised. The use of antibiotics and vaccines for therapy, as well as the use of medicinal plants in traditional medicine, is discussed. and root and stem bark infusions or decoctions were revealed to be the most common folklore treatments for cholera in rural communities. The potential of medicinal plants as anti- remedies based on their positive antibacterial assays, and mechanism of action is also presented. Finally, the development of innovative anti- therapeutics based on natural leads and compounds and adapted for use in resource-constrained cholera-prone areas is viewed as a potential option, to complement cholera prevention and treatment, particularly in resource-limited endemic areas.
霍乱是一种由[未提及病原体]引起的肠道感染病，对公众健康构成严重威胁，在发展中国家尤为如此。这篇叙述性综述探讨了津巴布韦霍乱暴发的驱动因素、挑战和可行的替代方案。使用电子数据库进行了文献检索，特别是科学Direct、谷歌学术和PubMed，以及论文和会议论文。证据表明，霍乱的流行病学以及风险因素包括：（1）极端干旱；（2）政治对卫生问题和供水的干预；（3）自然灾害；（4）移民；（5）水和卫生设施问题；（6）病原体的地方性特征及其耐药性的发展。强调可靠的清洁水供应以及适当的环境卫生和个人卫生是预防的关键。文中讨论了使用抗生素和疫苗进行治疗，以及传统医学中使用药用植物的情况。[未提及植物名称]的根和茎皮浸剂或煎剂被发现是农村社区治疗霍乱最常见的民间疗法。还介绍了药用植物基于其积极的抗菌试验作为抗霍乱药物的潜力及其作用机制。最后，基于天然先导化合物开发创新的抗霍乱疗法并使其适用于资源有限的霍乱高发地区，被视为一种潜在选择，以补充霍乱的预防和治疗，特别是在资源有限的流行地区。
