Hultgren B D, Menken B Z, Csallany A S
Am J Vet Res. 1986 Apr;47(4):818-9.
The effect of copper on thiobarbituric acid (TBA) reaction values, an index of lipid peroxidation, was examined in Bedlington Terriers, healthy dogs, and rats. High hepatic concentrations of copper appeared to lower TBA values in the inherited, chronic, progressive hepatic degeneration of Bedlington Terriers, a disease associated with copper toxicosis. The suspected TBA inhibition was confirmed when Cu2+ was added to homogenates of healthy dog or rat liver or a malondialdehyde standard. The amount of copper added approximated that in diseased Bedlington Terriers. Because of the interference by copper, the TBA test was judged to be an inappropriate test for the evaluation of lipid peroxidation in samples containing high copper concentrations such as those in diseased Bedlington Terriers.
在贝德灵顿梗犬、健康犬和大鼠中研究了铜对脂质过氧化指标硫代巴比妥酸（TBA）反应值的影响。在贝德灵顿梗犬遗传性、慢性、进行性肝变性（一种与铜中毒相关的疾病）中，肝脏中高浓度的铜似乎会降低TBA值。当向健康犬或大鼠肝脏匀浆或丙二醛标准品中添加Cu2+时，证实了对TBA的抑制作用。添加的铜量与患病贝德灵顿梗犬中的铜量相近。由于铜的干扰，TBA试验被判定为不适用于评估含高铜浓度样品（如患病贝德灵顿梗犬的样品）中的脂质过氧化。
