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葡萄糖酸锰作为使用磁共振成像技术观察饱腹状态下人体胃内片剂溶解的标志物的新用途。

Novel Use of Manganese Gluconate as a Marker for Visualization of Tablet Dissolution in the Fed Human Stomach Using Magnetic Resonance Imaging.

作者信息

Akbar Tejal, Gershkovich Pavel, Stamatopoulos Konstantinos, Gowland Penny A, Stolnik Snow, Butler James, Marciani Luca

机构信息

Nottingham Digestive Diseases Centre and National Institute for Health Research (NIHR), Nottingham Biomedical Research Centre, Nottingham University Hospitals NHS Trust and University of Nottingham, Nottingham NG7 2UH, U.K.

School of Pharmacy, University of Nottingham, Nottingham NG7 2RD, U.K.

出版信息

Mol Pharm. 2025 Jan 6;22(1):594-598. doi: 10.1021/acs.molpharmaceut.4c00854. Epub 2024 Dec 5.

DOI:10.1021/acs.molpharmaceut.4c00854
PMID:39637400
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11707739/
Abstract

Magnetic resonance imaging (MRI) of dry or solid materials in the gastrointestinal (GI) tract requires the use of contrast agents to enhance visualization of the dosage forms. In this study, we explore the novel use of manganese gluconate added to tablets. Manganese was released during tablet dissolution, generating a bright "halo" effect around the tablets, consistent with shortening of the longitudinal relaxation time of the bulk water surrounding the tablet. This is the first study to use MRI to directly image tablet dissolution in the fed stomach using a manganese gluconate contrast agent as dissolution marker.

摘要

对胃肠道（GI）中的干燥或固体物质进行磁共振成像（MRI）需要使用造影剂来增强剂型的可视化效果。在本研究中，我们探索了在片剂中添加葡萄糖酸锰的新用途。葡萄糖酸锰在片剂溶解过程中释放出来，在片剂周围产生明亮的“晕圈”效应，这与片剂周围大量水分子纵向弛豫时间缩短一致。这是第一项使用MRI以葡萄糖酸锰造影剂作为溶解标记物对饱腹状态下胃内片剂溶解情况进行直接成像的研究。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/52fe/11707739/1ede55c9f842/mp4c00854_0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/52fe/11707739/d5046954374e/mp4c00854_0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/52fe/11707739/eeeab47bd192/mp4c00854_0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/52fe/11707739/1ede55c9f842/mp4c00854_0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/52fe/11707739/d5046954374e/mp4c00854_0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/52fe/11707739/eeeab47bd192/mp4c00854_0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/52fe/11707739/1ede55c9f842/mp4c00854_0003.jpg

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