Hoekx Carlijn A, Martinez-Tellez Borja, Straat Maaike E, Bizino Maurice B, van Eyk Huub J, Lamb Hildebrandus J, Smit Johannes W A, Jazet Ingrid M, Nahon Kimberly J, Janssen Laura G M, Rensen Patrick C N, Boon Mariëtte R
Endocr Connect. 2025 Jan 6;14(2). doi: 10.1530/EC-24-0362. Print 2025 Feb 1.
Inflammation contributes to the development of type 2 diabetes mellitus (T2DM). While South Asians are more prone to develop T2DM than Europids, the inflammatory phenotype of the South Asian population remains relatively unknown. Therefore, we aimed to investigate potential differences in circulating levels of inflammation-related proteins in South Asians compared with Europids with T2DM.
In this secondary analysis of three randomized controlled trials, relative plasma levels of 73 inflammation-related proteins were measured using an Olink Target Inflammation panel and the serum fibroblast growth factor 21 (FGF21) concentration using an ELISA kit in Dutch South Asians (n = 47) and Dutch Europids (n = 49) with T2DM.
Of the 73 inflammation-related proteins, the relative plasma levels of six proteins were higher (stem cell factor, caspase-8, C-C motif chemokine ligand 28, interferon-gamma, sulfotransferase 1A1 and cystatin D; q-value <0.05), while relative levels of six proteins were lower (FGF21, human fibroblast collagenase, interferon-8, C-C motif chemokine ligand 4, C-X-C motif chemokine ligand 6 and monocyte chemoattractant protein-1; q-value <0.05) in South Asians compared with Europids. Of these, the effect size of FGF21 was the largest, particularly in females. We validated this finding by assessing the FGF21 concentration in serum. The FGF21 concentration was indeed lower in South Asians compared with Europids with T2DM in both males (-42.2%; P < 0.05) and females (-58.5%; P < 0.001).
Relative plasma levels of 12 inflammation-related proteins differed between South Asians and Europids with T2DM, with a significantly pronounced reduction in FGF21. In addition, the serum FGF21 concentration was significantly lower in South Asian males and females compared with Europids. Whether low FGF21 is an underlying cause or consequence of T2DM in South Asians remains to be determined.
ClinicalTrials.gov (NCT01761318, registration date 20-12-2012; NCT02660047, registration date 21-03-2018; and NCT03012113, registration date 06-01-2017).
炎症促进2型糖尿病（T2DM）的发展。虽然南亚人比欧洲裔更容易患T2DM，但南亚人群的炎症表型仍相对未知。因此，我们旨在研究与患T2DM的欧洲裔相比，南亚人循环中炎症相关蛋白水平的潜在差异。
在三项随机对照试验的二次分析中，使用Olink Target Inflammation检测板测定了73种炎症相关蛋白的相对血浆水平，并使用ELISA试剂盒测定了荷兰南亚人（n = 47）和荷兰欧洲裔（n = 49）患T2DM者的血清成纤维细胞生长因子21（FGF21）浓度。
在73种炎症相关蛋白中，6种蛋白的相对血浆水平较高（干细胞因子、半胱天冬酶-8、C-C基序趋化因子配体28、干扰素-γ、磺基转移酶1A1和胱抑素D；q值<0.05），而6种蛋白的相对水平较低（FGF21、人成纤维细胞胶原酶、干扰素-8、C-C基序趋化因子配体4、C-X-C基序趋化因子配体6和单核细胞趋化蛋白-1；q值<0.05），南亚人相比于欧洲裔。其中，FGF21的效应量最大，尤其是在女性中。我们通过评估血清中的FGF21浓度验证了这一发现。在患T2DM的男性（-42.2%；P < 0.05）和女性（-58.5%；P < ）中，南亚人的FGF21浓度确实低于欧洲裔。
患T2DM的南亚人和欧洲裔之间，12种炎症相关蛋白的相对血浆水平存在差异，FGF21显著降低。此外，南亚男性和女性的血清FGF21浓度明显低于欧洲裔。低FGF21是否是南亚人T2DM的潜在原因或后果仍有待确定。
ClinicalTrials.gov（NCT01761318，注册日期2012年12月20日；NCT02660047，注册日期2018年3月21日；以及NCT03012113，注册日期2017年1月6日）。 001
需注意，原文中“干扰素-8”可能有误，推测可能是“干扰素-β”之类更常见表述，翻译时保留了原文错误表述。
