Li Yiming, Liang Dongfang, Kabla Alexandre, Zhang Yuning, Ma Jun, Yang Xin
Department of Engineering, University of Cambridge, Cambridge, CB2 1PZ, UK.
Department of Engineering, University of Cambridge, Cambridge, CB2 1PZ, UK.
Comput Methods Programs Biomed. 2025 Mar;260:108530. doi: 10.1016/j.cmpb.2024.108530. Epub 2024 Nov 28.
Acoustofluidic manipulation of particles and biological cells has been widely applied in various biomedical and engineering applications, including effective separation of cancer cell, point-of-care diagnosis, and cell patterning for tissue engineering. It is often implemented within a polydimethylsiloxane (PDMS) microchannel, where standing surface acoustic waves (SSAW) are generated by sending two counter-propagating ultrasonic waves on a piezoelectric substrate.
In this paper, we develop a full cross-sectional model of the acoustofluidic device using finite element method, simulating the wave excitation on the substrate and wave propagation in both the fluid and the microchannel wall. This model allows us to carry out extensive parametric analyses concerning the acoustic properties of the fluid and the microchannel wall, as well as the dimensions of the channel, to explore their influences on the acoustic field, fluid flow and microparticle aggregation.
Our findings demonstrate an order-of-magnitude enhancement in acoustic pressure amplitude and aggregation speed and a reduction in the particle threshold radius to submicron levels, which can be achieved through adjustments to the channel height and the difference in acoustic impedance between the channel wall and the fluid. The optimum channel heights are determined, which depend on the acoustic properties of the channel wall. The particle trajectories, movements along pressure nodal planes, and terminal positions are identified, with relative strength between the radiation force and the streaming force compared in different combinations of parameters.
This work demonstrates that finetuning the dimensions and acoustic properties of the fluid and microchannel wall in acoustofluidic device can greatly enhance particle aggregation throughput and reduce constraints on particle size. Our findings offer valuable insights into device design and optimization.
颗粒和生物细胞的声流体操控已广泛应用于各种生物医学和工程应用中，包括癌细胞的有效分离、即时诊断以及组织工程中的细胞图案化。它通常在聚二甲基硅氧烷（PDMS）微通道内实现，通过在压电基板上发送两个反向传播的超声波来产生驻表面声波（SSAW）。
在本文中，我们使用有限元方法开发了声流体装置的全横截面模型，模拟了基板上的波激发以及流体和微通道壁中的波传播。该模型使我们能够对流体和微通道壁的声学特性以及通道尺寸进行广泛的参数分析，以探索它们对声场、流体流动和微粒聚集的影响。
我们的研究结果表明，通过调整通道高度以及通道壁与流体之间的声阻抗差异，可以实现声压振幅和聚集速度提高一个数量级，并且微粒阈值半径减小到亚微米水平。确定了最佳通道高度，其取决于通道壁的声学特性。识别了微粒轨迹、沿压力节点平面的运动以及终端位置，并比较了不同参数组合下辐射力和流体力之间的相对强度。
这项工作表明，微调声流体装置中流体和微通道壁的尺寸及声学特性可以极大地提高微粒聚集通量并减少对微粒尺寸的限制。我们的研究结果为装置设计和优化提供了有价值的见解。
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