Sugisawa Keigo, Takahashi Hiroyuki, Yamanari Masahiro, Okamoto Michiaki, Igarashi-Yokoi Tae, Azuma Takeshi, Miki Takayuki, Lu Hongshuang, Wu Yijin, Xiong Jianping, Ohno-Matsui Kyoko
Department of Ophthalmology and Visual Science, Institute of Science Tokyo, Tokyo, Japan.
Department of Ophthalmology and Visual Science, Institute of Science Tokyo, Tokyo, Japan.
Asia Pac J Ophthalmol (Phila). 2024 Nov-Dec;13(6):100117. doi: 10.1016/j.apjo.2024.100117. Epub 2024 Dec 4.
To observe the detailed structures of the inner and outer sclera at various stages of myopic maculopathy using polarization-sensitive optical coherence tomography (PS-OCT).
A PS-OCT system was developed for imaging the posterior eye using a swept laser. Data from highly myopic patients who underwent PS-OCT examination between May and June 2019 were used to generate birefringence images (showing scleral fiber density), optic axis images (visualizing the orientation of scleral fibers), and streamline images (providing 3D reconstructions to visualize scleral fiber stream).
A total of 89 eyes of 65 patients with high myopia were examined and analyzed for this study. The mean axial length was 30.4 ± 1.8 mm. In highly myopic eyes with a thin choroid, PS-OCT visualized the detailed structure of the sclera, and the optic axis images differentiated the direction of the inner and outer scleral fibers. In the optic axis and streamline images, the inner layer of the sclera contained radial fibers extending from the optic disc. In contrast, the outer layer of the sclera contained vertical fibers. With the progression of myopia, highly birefringent fibers first disappear in the inner scleral layer, followed by thinning of the inner layer itself. Subsequently, in the outer scleral layer, the number of highly birefringent fibers decreased. As myopic maculopathy worsened, the inner and outer layers of the sclera disintegrated.
PS-OCT is useful for observing the structures of the inner and outer sclera in various conditions of myopic maculopathy.
使用偏振敏感光学相干断层扫描（PS-OCT）观察近视性黄斑病变各阶段巩膜内外层的详细结构。
开发了一种PS-OCT系统，用于使用扫频激光对眼后段进行成像。使用2019年5月至6月间接受PS-OCT检查的高度近视患者的数据生成双折射图像（显示巩膜纤维密度）、视轴图像（可视化巩膜纤维的方向）和流线图像（提供三维重建以可视化巩膜纤维束）。
本研究共检查并分析了65例高度近视患者的89只眼。平均眼轴长度为30.4 ± 1.8毫米。在脉络膜薄的高度近视眼中，PS-OCT可观察到巩膜的详细结构，视轴图像可区分巩膜内外层纤维的方向。在视轴和流线图像中，巩膜内层包含从视盘延伸的放射状纤维。相比之下，巩膜外层包含垂直纤维。随着近视进展，高双折射纤维首先在内层巩膜中消失，随后内层本身变薄。随后，在外层巩膜中，高双折射纤维数量减少。随着近视性黄斑病变加重，巩膜内外层解体。
PS-OCT有助于观察近视性黄斑病变各种情况下巩膜内外层的结构。
