Zheng Yi, Li Guangping
Department of Emergency, Beijing Tongren Hospital, Capital Medical University, Beijing, China.
Department of Cardiology, Tianjin Key Laboratory of Ionic-Molecular Function of Cardiovascular Disease, Tianjin Institute of Cardiology, The Second Hospital of Tianjin Medical University, Tianjin, China.
Ann Indian Acad Neurol. 2024 Nov 1;27(6):619-628. doi: 10.4103/aian.aian_62_24. Epub 2024 Nov 25.
Recent research suggests that atrial fibrillation (AF) may influence the risk of developing Alzheimer's disease (AD) and vascular dementia (VaD). However, existing studies have provided inconsistent results, with some showing a significant association between AF and the risk of AD and VaD, while others do not. The objective of this study is to conduct a meta-analysis to investigate the association between AF and the risk of AD and VaD.
A comprehensive search was conducted in several databases, including PubMed, Web of Science, Embase, and Google Scholar, covering research published before December 2023. Odds ratios (ORs) or relative risks (RRs) and 95% confidence intervals (CIs) were calculated using Stata 12.0 software to assess the association between AF and the risk of AD or VaD.
The meta-analysis revealed a significant association between AF and an increased risk of AD, using a random effects model (OR/RR: 1.23, 95% CI: 1.13-1.34, I2 = 81.3%, P < 0.001). Similarly, a significant association was found between AF and an increased risk of VaD, using a random effects model (OR/RR: 1.80, 95% CI: 1.57-2.07, I2 = 82.1%, P < 0.001).
In summary, our comprehensive meta-analysis provides compelling evidence of a significant association between AF and an elevated risk of AD and VaD. The findings are corroborated by robust cross-sectional and longitudinal cohort studies, which further validate the observed link. However, further large-scale prospective studies are necessary to comprehensively investigate the relationship between AF and the risk of AD and VaD.
近期研究表明，心房颤动（AF）可能会影响患阿尔茨海默病（AD）和血管性痴呆（VaD）的风险。然而，现有研究结果并不一致，一些研究显示AF与AD和VaD风险之间存在显著关联，而另一些研究则未发现此关联。本研究的目的是进行一项荟萃分析，以探讨AF与AD和VaD风险之间的关联。
在多个数据库中进行了全面检索，包括PubMed、科学网、Embase和谷歌学术，涵盖2023年12月之前发表的研究。使用Stata 12.0软件计算比值比（OR）或相对风险（RR）以及95%置信区间（CI），以评估AF与AD或VaD风险之间的关联。
荟萃分析显示，使用随机效应模型，AF与AD风险增加之间存在显著关联（OR/RR：1.23，95%CI：1.13 - 1.34，I² = 81.3%，P < 0.001）。同样，使用随机效应模型发现AF与VaD风险增加之间存在显著关联（OR/RR：1.80，95%CI：1.57 - 2.07，I² = 82.1%，P < 0.001）。
总之，我们全面的荟萃分析提供了有力证据，证明AF与AD和VaD风险升高之间存在显著关联。横断面和纵向队列研究的有力证据进一步证实了观察到的联系。然而，需要进一步开展大规模前瞻性研究，以全面调查AF与AD和VaD风险之间的关系。
