Miao Yang, Zhao Fei, Guan Wei
Department of Pharmacology, The First People's Hospital of Yancheng, Yancheng, Jiangsu, China.
Department of Pharmacology, Jiangyin Hospital of Traditional Chinese Medicine, Jiangyin, Jiangsu, China.
Int J Neuropsychopharmacol. 2025 Feb 4;28(2). doi: 10.1093/ijnp/pyae064.
Depression is a prevalent and disabling disorder that poses serious problems in mental health care, and rapid antidepressants are novel treatments for this disorder. Cannabidiol (CBD), a nonintoxicating phytocannabinoid, is thought to have therapeutic potential due to its important neurological and anti-inflammatory properties. Despite major advances in pharmacotherapy in experimental animals, the exact mechanism of antidepressant-like effects remains to be elucidated.
In this paper, we review the current state of knowledge on the antidepressant properties of CBD in numerous experimental and clinical studies.
Accumulating evidence suggests that CBD has antidepressant properties in humans and animals with few side effects, suggesting that CBD may be a potential antidepressant. Furthermore, we discuss that CBD may therefore provide a potential treatment to exert antidepressant-like effects through various molecular targets, reducing inflammation, and enhancing neurogenesis.
Taken together with the growing popularity of CBD as a medicine, these findings extend the limited knowledge on the antidepressant effects of CBD. This potentially opens up new therapeutic means for the patients with depression.
抑郁症是一种普遍且使人致残的疾病，在精神卫生保健方面引发严重问题，而快速起效的抗抑郁药是针对该疾病的新型治疗方法。大麻二酚（CBD）是一种无成瘾性的植物大麻素，因其重要的神经学和抗炎特性而被认为具有治疗潜力。尽管在实验动物的药物治疗方面取得了重大进展，但抗抑郁样作用的确切机制仍有待阐明。
在本文中，我们回顾了众多实验和临床研究中关于CBD抗抑郁特性的当前知识状态。
越来越多的证据表明，CBD在人类和动物中具有抗抑郁特性且副作用较少，这表明CBD可能是一种潜在的抗抑郁药。此外，我们讨论了CBD因此可能通过各种分子靶点发挥抗抑郁样作用、减轻炎症并促进神经发生，从而提供一种潜在的治疗方法。
结合CBD作为药物越来越受欢迎的情况，这些发现扩展了关于CBD抗抑郁作用的有限知识。这可能为抑郁症患者开辟新的治疗手段。
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