Liu Fei, Cao Tianqing, Liu Yacong, Huang Dian, Zhang Jingxin
Department of Cardiology, Northern Jiangsu People's Hospital Affiliated to Yangzhou University, Yangzhou, Jiangsu, 225001, People's Republic of China.
Department of Radiology, Affiliated hospital of Jiangsu University, Zhenjiang, Jiangsu, 212001, People's Republic of China.
Nat Sci Sleep. 2024 Dec 6;16:1949-1958. doi: 10.2147/NSS.S482592. eCollection 2024.
The main purpose of this study is to evaluate the changes in sleep quality among patients with cirrhotic cardiomyopathy (CCM).
The study included liver cirrhosis patients aged 18-75 from Northern Jiangsu People's Hospital Affiliated to Yangzhou University and collected their clinical examination results to assess the clinical characteristics and related risk factors of patients with CCM.
The study found that the onset of CCM was not related to the etiology of inducing cirrhosis. Pittsburgh Sleep Quality Index (PSQI) score (odds ratio (OR) = 13.476, 95% confidence interval (CI) = 1.514-119.923, P = 0.020), absolute GLS (OR = 0.328, 95% CI = 0.210-0.510, P < 0.001), and N-terminal pro-B-type natriuretic peptide (NT-proBNP) (OR = 1.050, 95% CI = 1.025-1.076, P < 0.001) were identified as independent risk factors for inducing CCM.
In patients with CCM, a decrease in sleep quality often occurs. When cirrhotic patients also have poor sleep quality, along with a decrease in absolute Global Left Ventricular Strain (GLS) levels and an increase in NT-proBNP levels, these factors may pose a higher risk for CCM development. However, further validation of these research findings is required in larger sample sizes.
本研究的主要目的是评估肝硬化性心肌病（CCM）患者睡眠质量的变化。
该研究纳入了扬州大学附属苏北人民医院18 - 75岁的肝硬化患者，并收集他们的临床检查结果，以评估CCM患者的临床特征和相关危险因素。
研究发现，CCM的发病与诱发肝硬化的病因无关。匹兹堡睡眠质量指数（PSQI）评分（比值比（OR）= 13.476，95%置信区间（CI）= 1.514 - 119.923，P = 0.020）、绝对GLS（OR = 0.328，95% CI = 0.210 - 0.510，P < 0.001）和N末端B型利钠肽原（NT - proBNP）（OR = 1.050，95% CI = 1.025 - 1.076，P < 0.001）被确定为诱发CCM的独立危险因素。
在CCM患者中，睡眠质量常常下降。当肝硬化患者同时存在睡眠质量差，以及绝对整体左心室应变（GLS）水平降低和NT - proBNP水平升高时，这些因素可能会增加CCM发生的风险。然而，这些研究结果需要在更大样本量中进一步验证。
