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重组乙型肝炎疫苗接种后下运动神经元性面神经麻痹:一例报告及文献综述

Lower Motor Neuron Facial Nerve Paralysis Following Recombinant Hepatitis B Vaccine Administration: A Case Report and Literature Review.

作者信息

Ghouri Raza Gulzar, Naeem Hamza, Yousaf Mirza Rehan, Sohail Anam, Arshad Waqas, Basil Abdul Mabood

机构信息

Pakistan Kidney and Liver Institute and Research Center Lahore Pakistan.

King Edward Medical University Lahore Pakistan.

出版信息

Clin Case Rep. 2024 Dec 10;12(12):e9655. doi: 10.1002/ccr3.9655. eCollection 2024 Dec.

Abstract

The Hepatitis B vaccine's safety profile is considered safe, but sometimes neurological complications, like Bell's palsy (acute peripheral facial neuropathy), can occur after its administration. A 35-year-old female doctor experienced left-sided facial weakness and paralysis six days after getting the Hepatitis B vaccine. On examination, she had lower motor neuron facial nerve palsy. After excluding other causes, a diagnosis of Bell's palsy was made following Hepatitis B vaccine. She was treated with corticosteroids, antiviral medication, and physiotherapy, which led to a complete resolution over four weeks. Bell's palsy is still an uncommon potential side effect even though the advantages of the Hepatitis B vaccination exceed the risks. Further investigation is necessary to prove a conclusive link between the vaccine and its neurological side effects.

摘要

乙肝疫苗的安全性被认为是有保障的,但有时在接种后可能会出现神经并发症,如贝尔氏麻痹(急性周围性面神经麻痹)。一名35岁的女医生在接种乙肝疫苗六天后出现左侧面部无力和瘫痪。经检查,她患有下运动神经元性面神经麻痹。在排除其他病因后,诊断为接种乙肝疫苗后引发的贝尔氏麻痹。她接受了皮质类固醇、抗病毒药物和物理治疗,四周后完全康复。尽管乙肝疫苗接种的益处超过风险,但贝尔氏麻痹仍是一种罕见的潜在副作用。需要进一步调查以证实疫苗与其神经副作用之间的确切联系。

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