Wang Wencai, Liu Menghao, Wang Zun, Ye Wei, Li Xianfeng
Department of Neurosurgery, The Second Affiliated Hospital of Harbin Medical University, Harbin, China.
Front Endocrinol (Lausanne). 2024 Nov 28;15:1460278. doi: 10.3389/fendo.2024.1460278. eCollection 2024.
Pituitary tumors (PTs) are common benign intracranial tumors. Investigating the metabolites in serum and cerebrospinal fluid in PTs is essential to understanding the underlying biological mechanisms and identifying new biomarkers and therapeutic strategies.
We used the GWAS dataset of PTs from the FinnGen database, a dataset of 486 plasma metabolites from the GWAS catalog database, and a dataset of 338 cerebrospinal fluid (CSF) metabolites from the WADRC and WRAP study collections. An inverse variance weighting (IVW) approach was utilized as the mainly method to investigate causality between metabolites and PTs, supplemented by four complementary methods to strengthen our findings. Additionally, we utilized several sensitivity methods to guarantee the robustness of our findings.
The study identified 17 plasma metabolites and 10 CSF metabolites related to PTs. Among these, 11 metabolites indicated a significant positive causality with PTs, while 16 displayed a remarkable negative causality. Particularly, plasma levels of 3-dehydrocarnitine (OR = 2.73, 95% CI = 1.55-4.83, P = 0.001) and acetylcarnitine (OR = 0.35, 95% CI = 0.19-0.63, P = 0.001) were found to be significant exposure factors for PTs. Multiple sensitivity analyses confirm the robustness of the results. The study found no evidence of a reverse causality between PTs and the plasma levels of 3-dehydrocarnitine and acetylcarnitine.
The present study identified 27 metabolites associated with the incidence of PTs, among which 3-dehydrocarnitine and acetylcarnitine are the most noteworthy.
垂体瘤（PTs）是常见的颅内良性肿瘤。研究垂体瘤患者血清和脑脊液中的代谢物对于理解其潜在生物学机制、识别新的生物标志物和治疗策略至关重要。
我们使用了来自芬兰基因数据库的垂体瘤全基因组关联研究（GWAS）数据集、来自GWAS目录数据库的486种血浆代谢物数据集以及来自WADRC和WRAP研究集合的338种脑脊液（CSF）代谢物数据集。采用逆方差加权（IVW）方法作为研究代谢物与垂体瘤之间因果关系的主要方法，并辅以四种补充方法来强化我们的研究结果。此外，我们还使用了几种敏感性方法来确保研究结果的稳健性。
该研究确定了17种与垂体瘤相关的血浆代谢物和10种脑脊液代谢物。其中，11种代谢物与垂体瘤呈显著正因果关系，16种呈显著负因果关系。特别地，发现3-脱氢肉碱（OR = 2.73，95%CI = 1.55 - 4.83，P = 0.001）和乙酰肉碱（OR = 0.35，95%CI = 0.19 - 0.63，P = 0.001）的血浆水平是垂体瘤的显著暴露因素。多次敏感性分析证实了结果的稳健性。该研究未发现垂体瘤与3-脱氢肉碱和乙酰肉碱血浆水平之间存在反向因果关系的证据。
本研究确定了27种与垂体瘤发病率相关的代谢物，其中3-脱氢肉碱和乙酰肉碱最为值得关注。
