Waern U, Boberg J
Ups J Med Sci. 1979;84(3):203-14. doi: 10.3109/03009737909179157.
Two apparently healthy male groups, one 60 (n = 67) and one 50 (n = 367) years of age were compared with respect to blood glucose, serum lipid and serum insulin concentration and intravenous glucose tolerance. These groups were recruited from two health surveys performed on male populations of these ages in the municipality of Uppsala. The prevalence of diabetes mellitus in the two health survey populations were 4.5% and 0.9%, respectively. No significant differences in serum triglycerides, serum cholestrol and fasting serum insulin concentrations were found between the two age groups. Significantly higher k-values and higher early serum insulin response to i.v. glucose were found in the younger than in the older age group. The older age group was more obese, than the younger group. It is concluded that the prevalence of diabetes increases considerably in males between 50 and 60 years of age. In parallel, the prevalence of decreased glucose tolerance is increasing, which might partly be explained by increased body weight and partly by an impaired pancreatic beta-cell function.
对两组表面健康的男性进行了比较，一组年龄为60岁（n = 67），另一组为50岁（n = 367），比较内容包括血糖、血脂、血清胰岛素浓度及静脉葡萄糖耐量。这些组是从对乌普萨拉市这些年龄段男性人群进行的两项健康调查中招募的。两项健康调查人群中糖尿病的患病率分别为4.5%和0.9%。两个年龄组之间的血清甘油三酯、血清胆固醇和空腹血清胰岛素浓度未发现显著差异。较年轻年龄组比较年长年龄组的k值显著更高，且对静脉注射葡萄糖的早期血清胰岛素反应更高。较年长年龄组比年轻组更肥胖。得出的结论是，50至60岁男性中糖尿病的患病率显著增加。同时，葡萄糖耐量降低的患病率也在增加，这可能部分归因于体重增加，部分归因于胰腺β细胞功能受损。
