Xu Wanjun, Lin Zhixing, Kim Chan-Jin, Wang Zhaoran, Wang Tianzheng, Cortez-Jugo Christina, Caruso Frank
Department of Chemical Engineering, The University of Melbourne, Parkville, Victoria 3010, Australia.
Sci Adv. 2024 Dec 13;10(50):eads9542. doi: 10.1126/sciadv.ads9542.
Metal-organic networks have attracted widespread interest owing to their hybrid physicochemical properties. Natural biomolecules represent attractive building blocks for these materials because of their inherent biological function and high biocompatibility; however, assembling them into coordination network materials, especially nanoparticles (NPs), is challenging. Herein, we exploit the coordination between metal ions and phosphonate groups, which are present in many biomolecules, to form metal-biomolecule network (MBN) NPs in aqueous solution at room temperature. Various phosphonate-containing biomolecules, including plant phytate, DNA, and proteins, were used to assemble MBN NPs with tunable physicochemical properties (e.g., size). In addition to excellent biocompatibility and high cargo-loading efficiency (>95%), these two-component MBN NPs have various biological functionalities, including endosomal escape, immune regulation, and molecular recognition, thus offering advantages over nonbiomolecular-based coordination materials. This work expands our understanding of metal-organic chemistry with the emerging class of metal-biomolecule systems and provides a pathway for incorporating biofunctionalities into advanced coordination materials for diverse fields.
金属有机网络因其混合的物理化学性质而引起了广泛关注。天然生物分子因其固有的生物学功能和高生物相容性，成为这些材料有吸引力的构建模块；然而，将它们组装成配位网络材料，尤其是纳米颗粒（NPs），具有挑战性。在此，我们利用金属离子与许多生物分子中存在的膦酸酯基团之间的配位作用，在室温下于水溶液中形成金属 - 生物分子网络（MBN）纳米颗粒。各种含膦酸酯的生物分子，包括植物肌醇六磷酸、DNA和蛋白质，被用于组装具有可调物理化学性质（如尺寸）的MBN纳米颗粒。除了优异的生物相容性和高载药量效率（>95%）外，这些二元MBN纳米颗粒还具有多种生物学功能，包括内体逃逸、免疫调节和分子识别，因此比基于非生物分子的配位材料具有优势。这项工作扩展了我们对新兴的金属 - 生物分子系统类别的金属有机化学的理解，并为将生物功能整合到用于不同领域的先进配位材料中提供了一条途径。
