Rose-John Stefan, Jones Simon A
Department of Biochemistry, Christian-Albrechts-University Medical School, Kiel, Germany.
Department of Infection, Immunity and Biochemistry, The School of Medicine, Cardiff University, UK.
FEBS J. 2025 Feb;292(3):519-522. doi: 10.1111/febs.17355. Epub 2024 Dec 13.
Historically, cytokines belonging to the gp130 family bind to specific ligand-binding receptors that stimulate cell signaling through a receptor complex comprising gp130 or gp130 together with another structurally related signaling receptor. However, recent findings increasingly dispel these stereotypes and suggest that the receptor specificity of gp130-activating cytokines is less strict than originally assumed. Weitz et al. now provide the latest example of this pleiotropy and report that human interleukin-6 can bind and stimulate signaling via the interleukin-11 receptor. Possible biological and therapeutic consequences of these findings are discussed.
从历史上看，属于gp130家族的细胞因子与特定的配体结合受体结合，这些受体通过包含gp130或gp130与另一种结构相关的信号受体的受体复合物来刺激细胞信号传导。然而，最近的研究结果越来越多地消除了这些刻板印象，并表明激活gp130的细胞因子的受体特异性不如最初设想的那么严格。魏茨等人现在提供了这种多效性的最新例子，并报告说人类白细胞介素-6可以通过白细胞介素-11受体结合并刺激信号传导。讨论了这些发现可能的生物学和治疗后果。
