单克隆抗体可阻断菠萝蛋白酶介导的人胎盘碱性磷酸酶从培养的癌细胞中的释放。
Monoclonal antibodies block the bromelain-mediated release of human placental alkaline phosphatase from cultured cancer cells.
作者信息
Jemmerson R, Millan J L, Klier F G, Fishman W H
出版信息
FEBS Lett. 1985 Jan 7;179(2):316-20. doi: 10.1016/0014-5793(85)80542-1.
PMID:3967756
Abstract
Certain monoclonal antibodies (mAbs) to human placental alkaline phosphatase (PLAP) block bromelain cleavage of a 2-kDa segment from each of the two polypeptide chains of PLAP. These mAbs also prevent the release of PLAP from cultured cancer cell surfaces by bromelain. Such proteolysis-blocking mAbs serve as tools to specifically modify the molecular topography of cell surfaces by protease treatment.
摘要
某些针对人胎盘碱性磷酸酶（PLAP）的单克隆抗体（mAb）可阻断菠萝蛋白酶对PLAP两条多肽链中每一条链上一个2 kDa片段的切割。这些mAb还可防止菠萝蛋白酶将PLAP从培养的癌细胞表面释放出来。这种蛋白水解阻断性mAb可作为通过蛋白酶处理特异性修饰细胞表面分子拓扑结构的工具。
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