• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

METTL3作为胃癌潜在的治疗靶点。

METTL3 as a potential therapeutic target in gastric cancer.

作者信息

Yu Zhefei, Yang Yang

机构信息

The First Affiliated Hospital of Guangxi University Of Chinese Medicine, Nanning, Guangxi, China.

出版信息

Front Oncol. 2024 Nov 29;14:1483435. doi: 10.3389/fonc.2024.1483435. eCollection 2024.

DOI:10.3389/fonc.2024.1483435
PMID:39678510
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11638058/
Abstract

Gastric cancer (GC) is one of the leading causes of cancer-related death worldwide. N6-methyladenosine (m6A) modification is the most prominent epigenetic modification of eukaryotic mRNAs, and methyltransferase-like 3 (METTL3), a core component of the methyltransferase complex, catalyzes m6A modification. The results of previous studies indicate that the expression level of METTL3 is significantly elevated in gastric cancer tissues and cells. In addition, fluctuations in m6A levels induced by METTL3 are closely associated with the malignant progression of tumors as well as the poor prognosis of patients with gastric cancer. In this review, we focus on the potential mechanism of METTL3 in gastric cancer, and through our analysis, we suggest that targeting METTL3 could be a new therapeutic tool for treating GC.

摘要

胃癌（GC）是全球癌症相关死亡的主要原因之一。N6-甲基腺苷（m6A）修饰是真核生物mRNA最显著的表观遗传修饰，甲基转移酶样3（METTL3）作为甲基转移酶复合物的核心成分，催化m6A修饰。先前的研究结果表明，METTL3在胃癌组织和细胞中的表达水平显著升高。此外，METTL3诱导的m6A水平波动与肿瘤的恶性进展以及胃癌患者的不良预后密切相关。在本综述中，我们聚焦于METTL3在胃癌中的潜在机制，通过分析，我们认为靶向METTL3可能是治疗GC的一种新的治疗手段。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6e8f/11638058/88408dad2328/fonc-14-1483435-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6e8f/11638058/fa614a9aa5cc/fonc-14-1483435-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6e8f/11638058/88408dad2328/fonc-14-1483435-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6e8f/11638058/fa614a9aa5cc/fonc-14-1483435-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6e8f/11638058/88408dad2328/fonc-14-1483435-g002.jpg

相似文献

1
METTL3 as a potential therapeutic target in gastric cancer.METTL3作为胃癌潜在的治疗靶点。
Front Oncol. 2024 Nov 29;14:1483435. doi: 10.3389/fonc.2024.1483435. eCollection 2024.
2
METTL3-mediated N6-methyladenosine modification is critical for epithelial-mesenchymal transition and metastasis of gastric cancer.METTL3 介导的 N6-甲基腺苷修饰对于胃癌的上皮-间质转化和转移至关重要。
Mol Cancer. 2019 Oct 13;18(1):142. doi: 10.1186/s12943-019-1065-4.
3
The m6A Methyltransferase METTL3-Mediated N6-Methyladenosine Modification of DEK mRNA to Promote Gastric Cancer Cell Growth and Metastasis.m6A 甲基转移酶 METTL3 介导的 DEK mRNA 的 N6-甲基腺苷化修饰促进胃癌细胞生长和转移。
Int J Mol Sci. 2022 Jun 9;23(12):6451. doi: 10.3390/ijms23126451.
4
METTL3 Promotes the Progression of Gastric Cancer via Targeting the MYC Pathway.METTL3通过靶向MYC通路促进胃癌进展。
Front Oncol. 2020 Feb 26;10:115. doi: 10.3389/fonc.2020.00115. eCollection 2020.
5
METTL3-mediated mA modification of HDGF mRNA promotes gastric cancer progression and has prognostic significance.METTL3 介导的 HDGF mRNA mA 修饰促进胃癌进展并具有预后意义。
Gut. 2020 Jul;69(7):1193-1205. doi: 10.1136/gutjnl-2019-319639. Epub 2019 Oct 3.
6
Dysregulated N6-methyladenosine methylation writer METTL3 contributes to the proliferation and migration of gastric cancer.失调的 N6-甲基腺苷甲基化写入器 METTL3 促进胃癌的增殖和迁移。
J Cell Physiol. 2020 Jan;235(1):548-562. doi: 10.1002/jcp.28994. Epub 2019 Jun 24.
7
RNA N6-methyladenosine methyltransferase-like 3 promotes liver cancer progression through YTHDF2-dependent posttranscriptional silencing of SOCS2.RNA N6-甲基腺苷甲基转移酶样 3 通过 YTHDF2 依赖的 SOCS2 转录后沉默促进肝癌进展。
Hepatology. 2018 Jun;67(6):2254-2270. doi: 10.1002/hep.29683. Epub 2018 Apr 19.
8
METTL3-Regulated lncRNA SNHG7 Drives MNNG-Induced Epithelial-Mesenchymal Transition in Gastric Precancerous Lesions.METTL3调控的长链非编码RNA SNHG7驱动MNNG诱导的胃癌前病变上皮-间质转化
Toxics. 2024 Aug 6;12(8):573. doi: 10.3390/toxics12080573.
9
m6A Methyltransferase 3 Promotes the Proliferation and Migration of Gastric Cancer Cells through the m6A Modification of YAP1.m6A甲基转移酶3通过对YAP1进行m6A修饰促进胃癌细胞的增殖和迁移。
J Oncol. 2021 Aug 4;2021:8875424. doi: 10.1155/2021/8875424. eCollection 2021.
10
Cross talk between RNA N6-methyladenosine methyltransferase-like 3 and miR-186 regulates hepatoblastoma progression through Wnt/β-catenin signalling pathway.RNA N6-甲基腺苷甲基转移酶样 3 与 miR-186 之间的串扰通过 Wnt/β-catenin 信号通路调控肝癌进展。
Cell Prolif. 2020 Mar;53(3):e12768. doi: 10.1111/cpr.12768. Epub 2020 Jan 22.

本文引用的文献

1
Targeted degradation of METTL3 against acute myeloid leukemia and gastric cancer.靶向降解 METTL3 治疗急性髓系白血病和胃癌。
Eur J Med Chem. 2024 Dec 5;279:116843. doi: 10.1016/j.ejmech.2024.116843. Epub 2024 Sep 6.
2
PCAF-mediated acetylation of METTL3 impairs mRNA translation efficiency in response to oxidative stress.PCAF 通过乙酰化 METTL3 来降低氧化应激下的 mRNA 翻译效率。
Sci China Life Sci. 2024 Oct;67(10):2157-2168. doi: 10.1007/s11427-023-2535-x. Epub 2024 Aug 3.
3
Discovery of a PROTAC degrader for METTL3-METTL14 complex.
发现一种用于 METTL3-METTL14 复合物的 PROTAC 降解剂。
Cell Chem Biol. 2024 Jan 18;31(1):177-183.e17. doi: 10.1016/j.chembiol.2023.12.009. Epub 2024 Jan 8.
4
Depicting the Profile of METTL3-Mediated lncRNA m6A Modification Variants and Identified SNHG7 as a Prognostic Indicator of MNNG-Induced Gastric Cancer.描绘METTL3介导的lncRNA m6A修饰变体图谱并鉴定SNHG7为MNNG诱导的胃癌的预后指标。
Toxics. 2023 Nov 20;11(11):944. doi: 10.3390/toxics11110944.
5
METTL3 promotes drug resistance to oxaliplatin in gastric cancer cells through DNA repair pathway.METTL3通过DNA修复途径促进胃癌细胞对奥沙利铂的耐药性。
Front Pharmacol. 2023 Sep 26;14:1257410. doi: 10.3389/fphar.2023.1257410. eCollection 2023.
6
Gastric cancer derived exosomal THBS1 enhanced Vγ9Vδ2 T-cell function through activating RIG-I-like receptor signaling pathway in a N6-methyladenosine methylation dependent manner.胃癌来源的外泌体THBS1通过以N6-甲基腺苷甲基化依赖的方式激活视黄酸诱导基因I样受体信号通路，增强Vγ9Vδ2 T细胞功能。
Cancer Lett. 2023 Nov 1;576:216410. doi: 10.1016/j.canlet.2023.216410. Epub 2023 Oct 7.
7
miR-181-5p/KLHL5 Promoted Proliferation and Migration of Gastric Cancer Through Activating METTL3-Mediated m6A Process.miR-181-5p/KLHL5 通过激活 METTL3 介导的 m6A 过程促进胃癌的增殖和迁移。
Mol Biotechnol. 2024 Sep;66(9):2415-2425. doi: 10.1007/s12033-023-00877-x. Epub 2023 Sep 21.
8
RNautophagic regulation of DNMT3a-dependent DNA methylation by Linc00942 enhances chemoresistance in gastric cancer.Linc00942 通过调控自噬增强胃癌中 DNMT3a 依赖的 DNA 甲基化从而增强化疗耐药性。
Clin Transl Med. 2023 Jul;13(7):e1337. doi: 10.1002/ctm2.1337.
9
The transcription factor ATF2 promotes gastric cancer progression by activating the METTL3/cyclin D1 pathway.转录因子 ATF2 通过激活 METTL3/细胞周期蛋白 D1 通路促进胃癌进展。
Drug Dev Res. 2023 Sep;84(6):1325-1334. doi: 10.1002/ddr.22092. Epub 2023 Jul 8.
10
Prognostic significance of N6-methyladenosine-modified related chemotransferase METTL3 in gastric carcinoma: Evidence from meta-analysis.N6-甲基腺嘌呤修饰相关化学转移酶METTL3在胃癌中的预后意义：来自荟萃分析的证据
Int J Biol Markers. 2023 Dec;38(3-4):185-193. doi: 10.1177/03936155231184908. Epub 2023 Jul 2.