与口外注射法相比，口内注射肉毒杆菌毒素对肌筋膜疼痛患者疼痛及生活质量的影响：一项随机临床试验

Effectiveness of intra-oral botulinum toxin injection in comparison to the extra-oral approach on pain and quality of life in patients with myofascial pain: a randomized clinical trial.

作者信息

Shabaan Alshaimaa Ahmed, Kassem Islam, Aboulmagd Inass, Amer Islam A, Shaaban Ahmed, Abd-El-Ghafour Mohamed, Refahee Shaimaa Mohsen

机构信息

Department of Oral & Maxillofacial Surgery, Faculty of Dentistry, Fayoum University, Fayoum, Egypt.

Consultant Oral and Maxillofacial Surgery, Main University Hospital, Alexandria University, Alexandria, Egypt.

出版信息

Clin Oral Investig. 2024 Dec 17;29(1):18. doi: 10.1007/s00784-024-06051-0.

DOI:10.1007/s00784-024-06051-0

PMID:39681752

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11649703/

Abstract

OBJECTIVE

To evaluate and compare the effectiveness of the ultrasound-guided intra-oral and extra-oral transcutaneous injection techniques on the clinical outcome variables in patients with myofascial trigger points within the masseter muscle.

MATERIALS AND METHODS

This prospective randomized trial included 42 patients diagnosed with myofascial pain. Patients were randomly allocated into one of two groups based on the technique of trigger point injection: intraoral and extraoral injection technique groups. Each trigger point was injected with 0.1 ml of botulinum-A toxin guided by ultrasound. Pain intensity, mouth opening, and patient quality of life were monitored six months post-injection.

RESULTS

The pain scores were significantly higher in the extraoral group during all follow-up assessments, whereas the MMO was considerably greater in the intraoral group up to three months of follow-up (p < 0.008). However, the difference in MMO ceased to be statistically non-significant after six months of follow-up (p = 0.927). Additionally, the patient's quality of life score was significantly higher in the intraoral group compared to the extraoral group (p < 0.001) at both the three- and six-month follow-ups.

CONCLUSION

The intraoral injection technique might be an effective treatment modality for myofascial trigger points in the masseter muscle. It produces pain relief, increases mouth opening, and enhances the overall quality of life compared to the extraoral injection technique.

CLINICAL SIGNIFICANCE

The intraoral injection technique for myofascial trigger points is more effective than the extraoral technique; it reduces the need for additional injections, saves money, and enhances patients' quality of life.