Triantafyllou Aggeliki, Lelovas Pavlos P, Galanos Antonis, Venetsanou Kyriaki, Passali Christina, Patsaki Anastasia, Pitidis Dimitrios, Kourkoulis Stavros K, Dontas Ismene A
Laboratory for Research of the Musculoskeletal System "Th. Garofalides", School of Medicine, National & Kapodistrian University of Athens, KAT Hospital, 14561 Athens, Greece.
1st Intensive Care Unit, KAT Hospital, 14561 Athens, Greece.
Nutrients. 2024 Nov 26;16(23):4046. doi: 10.3390/nu16234046.
: The beneficial effects of ω-3 fatty acids on the cardiovascular system have been observed in many epidemiological studies; however, their effects on the skeleton and in particular on postmenopausal bone loss appear to vary. The present study's purpose was to investigate the effects of oral fish oil (rich in ω-3 fatty acids) consumption on bone, plasma, and inflammation parameters in the ovariectomized (Ovx) rat model of osteopenia. : Four Groups of ten rats each were separated into Non-Ovx receiving fish oil (2.8 g/kg body weight) (Non-Ovx + FO), Non-Ovx receiving isocaloric corn oil (Non-Ovx + CO), Ovx receiving fish oil (Ovx + FO), and Ovx receiving corn oil (Ovx + CO) daily for 4 months. : Tibial bone mineral density percentage changes from baseline were +4.09% in Non-Ovx + FO rats versus -2.99% in Non-Ovx + CO rats ( NS), and -5.73% in Ovx + FO rats versus -14.12% in Ovx + CO rats ( = 0.070), indicating a tendency to protect from bone loss. Fish oil exerted a beneficial effect on bone strength, as shown by significantly increased femoral fracture stress in Ovx + FO, compared to Ovx + CO rats ( = 0.05). The plasma's total cholesterol was significantly reduced in both FO Groups versus the CO Groups ( < 0.001), while HDL-cholesterol decreased slightly in both FO Groups, significantly ( < 0.001) between Non-Ovx + FO versus Non-Ovx + CO. Interleukin 6 was reduced in both FO Groups, indicating the anti-inflammatory effect of fish oil consumption, which was highly significant ( < 0.001) between Non-Ovx + FO versus Non-Ovx + CO. Interleukin 10, TNF-α, and RANKL displayed non-significant changes. : Among the skeletal and blood parameters studied, several, but not all, demonstrated a mild to significant beneficial effect of four-month fish oil consumption.
许多流行病学研究都观察到了ω-3脂肪酸对心血管系统的有益作用；然而，它们对骨骼尤其是绝经后骨质流失的影响似乎有所不同。本研究的目的是调查口服富含ω-3脂肪酸的鱼油对去卵巢（Ovx）骨质疏松大鼠模型的骨骼、血浆和炎症参数的影响。：将四组每组十只大鼠分别分为接受鱼油（2.8克/千克体重）的未去卵巢组（未去卵巢+鱼油）、接受等热量玉米油的未去卵巢组（未去卵巢+玉米油）、接受鱼油的去卵巢组（去卵巢+鱼油）和接受玉米油的去卵巢组（去卵巢+玉米油），每天给药4个月。：未去卵巢+鱼油组大鼠胫骨骨矿物质密度相对于基线的百分比变化为+4.09%，未去卵巢+玉米油组为-2.99%（无显著性差异），去卵巢+鱼油组为-5.73%，去卵巢+玉米油组为-14.12%（P = 0.070），表明有预防骨质流失的趋势。鱼油对骨骼强度有有益作用，与去卵巢+玉米油组大鼠相比，去卵巢+鱼油组大鼠股骨骨折应力显著增加（P = 0.05）。与玉米油组相比，两个鱼油组的血浆总胆固醇均显著降低（P < 0.001），而两个鱼油组的高密度脂蛋白胆固醇均略有下降，未去卵巢+鱼油组与未去卵巢+玉米油组之间差异显著（P < 0.001）。两个鱼油组的白细胞介素6均降低，表明食用鱼油具有抗炎作用，未去卵巢+鱼油组与未去卵巢+玉米油组之间差异极显著（P < 0.001）。白细胞介素10、肿瘤坏死因子-α和核因子κB受体活化因子配体显示无显著变化。：在所研究的骨骼和血液参数中，有几个但不是全部显示出四个月食用鱼油有轻度到显著的有益作用。
