Mirzwa-Mróz Ewa, Zieniuk Bartłomiej, Yin Zhimin, Pawełkowicz Magdalena
Division of Plant Pathology, Department of Plant Protection, Institute of Horticultural Sciences, Warsaw University of Life Sciences-SGGW, 159 Nowoursynowska Str., 02-776 Warsaw, Poland.
Department of Chemistry, Institute of Food Sciences, Warsaw University of Life Sciences SGGW, 159C Nowoursynowska Str., 02-776 Warsaw, Poland.
Int J Mol Sci. 2024 Nov 27;25(23):12726. doi: 10.3390/ijms252312726.
Cucurbit downy mildew, caused by , is a devastating disease in cucumbers that leads to significant yield losses in many cucurbit-growing regions worldwide. Developing resistant cucumber varieties is a sustainable approach to managing this disease, especially given the limitations of chemical control and the evolving nature of pathogens. This article reviews the genetic basis of downy mildew resistance in cucumbers, emphasizing key resistance (R) genes and quantitative trait loci (QTLs) that have been mapped. Recent advances in molecular breeding tools, including marker-assisted selection (MAS), genomic selection (GS), and CRISPR/Cas9 genome editing, have accelerated the development of resistant cultivars. This review also explores the role of transcriptomics, genomics, and other 'omics' technologies in unraveling the molecular mechanisms behind resistance and offers insights into the future of breeding strategies aimed at long-term disease management. Management strategies for cucurbit downy mildew are discussed, along with the potential impacts of climate change on the occurrence and severity of downy mildew, highlighting how changing environmental conditions may influence disease dynamics. Integrating these advanced genetic approaches with traditional breeding promises to accelerate the development of downy mildew-resistant cucumber varieties, contributing to the sustainability and resilience of cucumber production.
由[病原菌名称未给出]引起的黄瓜霜霉病，是黄瓜上一种极具破坏性的病害，在全球许多黄瓜种植地区都会导致严重的产量损失。培育抗病黄瓜品种是防治这种病害的一种可持续方法，特别是考虑到化学防治的局限性以及病原菌不断演变的特性。本文综述了黄瓜霜霉病抗性的遗传基础，重点介绍了已定位的关键抗性（R）基因和数量性状位点（QTL）。分子育种工具的最新进展，包括标记辅助选择（MAS）、基因组选择（GS）和CRISPR/Cas9基因组编辑，加速了抗病品种的培育。本综述还探讨了转录组学、基因组学和其他“组学”技术在揭示抗性背后分子机制方面的作用，并对旨在进行长期病害管理的育种策略的未来发展提供了见解。文中讨论了黄瓜霜霉病的管理策略，以及气候变化对霜霉病发生和严重程度的潜在影响，强调了不断变化的环境条件可能如何影响病害动态。将这些先进的遗传方法与传统育种相结合，有望加速抗霜霉病黄瓜品种的培育，为黄瓜生产的可持续性和恢复力做出贡献。
