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双侧顺行性脑灌注在脑保护中的疗效如何?

What Is the Efficacy of Bilateral Antegrade Cerebral Perfusion in Cerebral Protection?

作者信息

Iner Hasan, Peker Ihsan, Karaagac Erturk, Yazman Serkan, Durmaz Huseyin, Kandemir Cagri, Tellioglu Tahsin Murat, Gokalp Orhan, Yilik Levent, Gurbuz Ali

机构信息

Department of Cardiovascular Surgery, Ataturk Training and Research Hospital, Izmir Katip Celebi University, Karabaglar, Izmir 35360, Türkiye.

Department of Cardiovascular Surgery, Konya City Hospital, Karatay, Konya 42020, Türkiye.

出版信息

J Clin Med. 2024 Dec 7;13(23):7452. doi: 10.3390/jcm13237452.

Abstract

Acute type A aortic dissection is among the many types of catastrophic cardiovascular emergencies. The development of serious morbidity, especially neurological complications after the operation, remains a huge threat. We aimed to present comparatively the results of using unilateral or bilateral antegrade cerebral perfusion to minimize these threats and to demonstrate the postoperative effects of antegrade cerebral perfusion choices. The 147 patients who underwent emergency acute type A aortic dissection surgery between January 2018 and January 2023 were evaluated retrospectively. The patients were divided into two groups: those who underwent unilateral antegrade cerebral perfusion (Group 1) (n = 89) and those who underwent bilateral antegrade cerebral perfusion (Group 2) (n = 59). Baseline demographics, and preoperative, operative, and postoperative data of patients were compared statistically. When the analyses of baseline demographics, and preoperative and operative data were evaluated, no significant difference was found between the groups. In addition, when comparing postoperative results, no statistical difference was found between the groups except for new-onset permanent neurological complications. The rate of postoperative new-onset permanent neurological complications was found to be 17.9% in group 1, where unilateral antegrade cerebral perfusion was applied, and 5.1% in group 2, where bilateral antegrade cerebral perfusion was applied, and this comparison was statistically significant. The competence of the Willis Polygon should not be relied upon without any evidence, and we believe that bilateral antegrade cerebral perfusion can be performed with a technique that does not compromise surgical comfort.

摘要

急性A型主动脉夹层是众多灾难性心血管急症之一。严重并发症的发生,尤其是术后神经并发症,仍然是一个巨大的威胁。我们旨在比较单侧或双侧顺行性脑灌注的效果,以尽量减少这些威胁,并展示顺行性脑灌注选择的术后效果。对2018年1月至2023年1月期间接受急诊急性A型主动脉夹层手术的147例患者进行回顾性评估。患者分为两组:接受单侧顺行性脑灌注的患者(第1组)(n = 89)和接受双侧顺行性脑灌注的患者(第2组)(n = 59)。对患者的基线人口统计学数据以及术前、术中及术后数据进行统计学比较。在评估基线人口统计学数据以及术前和术中数据时,两组之间未发现显著差异。此外,在比较术后结果时,除了新发永久性神经并发症外,两组之间未发现统计学差异。发现应用单侧顺行性脑灌注的第1组术后新发永久性神经并发症发生率为17.9%,应用双侧顺行性脑灌注的第2组为5.1%,这种比较具有统计学意义。在没有任何证据的情况下,不应依赖Willis环的功能,并且我们认为双侧顺行性脑灌注可以通过一种不影响手术舒适度的技术来进行。

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