Schuster Antonia, Steines Louisa, Banas Bernhard, Bergler Tobias
Department of Nephrology, University Hospital Regensburg, Franz-Josef-Strauß-Allee 11, 93053 Regensburg, Germany.
Medical Clinic III-Nephrology, Hospital Ingolstadt, Krumenauerstr. 25, 85049 Ingolstadt, Germany.
J Clin Med. 2024 Dec 7;13(23):7454. doi: 10.3390/jcm13237454.
Even today, a non-invasive biomarker to identify donors with enhanced risk for renal impairment is missing. Dickkopf 3 (DKK3) can cause tubulointerstitial fibrosis and is associated with rapid eGFR loss. The aim of our work was to analyze whether DKK3 can be used as a non-invasive alert marker for an increased risk of loss of kidney function in living kidney donors (LKDs). All donors who were examined between July 2022 and June 2023 ( = 117) were included. DKK3 was measured in the urine. The collected patient-related data were compared with parameters before donation. The study cohort was stratified by DKK3 values (</≥200). In the follow-up, 89 donors had a DKK3 value < 200 (group 1) and 28 donors had a DKK3 value ≥200 (group 2). During post-donation follow-up, renal function in group 1 was significantly better than that in group 2 ( = 0.01), although no difference in renal function before donation was detected ( = 0.84). Group 2 showed also a greater eGFR loss over time than group 1. LKDs with elevated DKK3 levels in the FU had impaired kidney function without evidence of increased risk factors pre-donation. DKK3 can represent a possible monitoring tool for kidney function in LKDs.
即使在今天，仍缺乏一种用于识别肾功能损害风险增加的供体的非侵入性生物标志物。Dickkopf 3（DKK3）可导致肾小管间质纤维化，并与估算肾小球滤过率（eGFR）快速下降相关。我们研究的目的是分析DKK3是否可作为活体肾供体（LKD）肾功能丧失风险增加的非侵入性警示标志物。纳入了2022年7月至2023年6月期间接受检查的所有供体（n = 117）。检测尿中的DKK3。将收集的患者相关数据与捐献前的参数进行比较。研究队列根据DKK3值（< /≥200）进行分层。在随访中，89名供体的DKK3值<200（第1组），28名供体的DKK3值≥200（第2组）。在捐献后随访期间，第1组的肾功能明显优于第2组（P = 0.01），尽管在捐献前未检测到肾功能差异（P = 0.84）。随着时间的推移，第2组的eGFR下降也比第1组更大。随访中DKK3水平升高的LKD肾功能受损，且捐献前无危险因素增加的证据。DKK3可作为LKD肾功能的一种可能的监测工具。
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