Shands K N, Ho J L, Meyer R D, Gorman G W, Edelstein P H, Mallison G F, Finegold S M, Fraser D W
JAMA. 1985 Mar 8;253(10):1412-6.
A three-year epidemic of legionnaires' disease in a hospital was dramatically curtailed following hyperchlorination of the potable water supply. The hypothesis that potable water was the source for the outbreak was further supported by isolation of Legionella pneumophila (the agent of legionnaires' disease) from the hospital water supply, observation that a sudden upsurge had occurred in the number of cases following a peculiar manipulation of the hospital water system, and documentation of a 30-fold increase in concentration of organisms in the water when this manipulation was artificially recreated. Thus, potable water may be an important source of epidemic legionnaires' disease and continuous hyperchlorination a method of control.
一家医院爆发了为期三年的军团病疫情，在对饮用水供应进行强化氯化处理后，疫情得到了显著遏制。饮用水是此次疫情源头这一假设，得到了以下证据的进一步支持：从医院供水系统中分离出嗜肺军团菌（军团病病原体）；观察到医院水系统经过特殊操作后病例数突然激增；以及当人工重现该操作时，水中微生物浓度增加了30倍的记录。因此，饮用水可能是军团病疫情的一个重要源头，持续进行强化氯化处理是一种控制方法。
