Di Zazzo Antonio, De Gregorio Chiara, Spelta Sara, Demircan Senol
Ophthalmology Complex Operative Unit, University Campus Bio-Medico, Rome, Italy.
Rare Corneal Diseases Center, Campus Bio-Medico University Hospital Foundation, Rome, Italy.
Eur J Ophthalmol. 2025 Jul;35(4):1445-1455. doi: 10.1177/11206721241305661. Epub 2024 Dec 18.
ObjectiveThis research investigates the associations between Dry Eye Disease (DED), pain perception, and mental health, focusing on how neuropathic pain influences treatment efficacy and patients' quality of life.Methods and ResultsThe study delves into the complexity of DED by assessing the correlation between ocular pain, depression, PTSD, and systemic pain conditions. It highlights the role of chronic neuropathic pain in DED and the nociceptive hypothesis, which suggests that psychological stress can exacerbate DED symptoms. Additionally, it explores diagnostic and management strategies for DED, emphasizing the importance of considering psychological aspects to improve patient care.ConclusionsThe intricate nature of DED, closely linked to mental health issues, requires a comprehensive diagnostic and therapeutic approach. Addressing neuropathic pain and psychological factors is crucial for effective DED management. Future efforts should focus on developing specific interventions targeting DED's physical and emotional impacts to enhance overall patient well-being.
目的
本研究调查干眼疾病（DED）、疼痛感知与心理健康之间的关联，重点关注神经性疼痛如何影响治疗效果和患者生活质量。
方法与结果
该研究通过评估眼部疼痛、抑郁、创伤后应激障碍（PTSD）和全身性疼痛状况之间的相关性，深入探究DED的复杂性。它强调了慢性神经性疼痛在DED中的作用以及伤害感受假说，该假说认为心理压力会加剧DED症状。此外，它还探索了DED的诊断和管理策略，强调考虑心理因素对改善患者护理的重要性。
结论
DED的复杂性与心理健康问题密切相关，需要综合的诊断和治疗方法。解决神经性疼痛和心理因素对于有效管理DED至关重要。未来的努力应集中在开发针对DED身体和情感影响的特定干预措施，以提高患者的整体幸福感。
