在就诊于艾滋病病毒和性健康诊所的青少年及青年成年人中丙型肝炎病毒感染率很高。

High prevalence of hepatitis C virus infection among adolescents and young adults attending HIV and sexual health clinics.

作者信息

Pansue Krisanee, Promsena Pathariya, Songtaweesin Wipaporn Natalie, Moonwong Juthamanee, Ryan Juliet, Kawichai Surinda, Thanapirom Kessarin, Puthanakit Thanyawee

机构信息

Department of Pediatrics, Division of Infectious Disease, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.

Center of Excellence for Pediatric Infectious Diseases and Vaccines, Chulalongkorn University, Bangkok, Thailand.

出版信息

Int J STD AIDS. 2025 Mar;36(4):289-296. doi: 10.1177/09564624241302231. Epub 2024 Dec 18.

DOI:10.1177/09564624241302231

PMID:39693642

Abstract

BACKGROUND

The prevalence of hepatitis C virus (HCV) infection among Thai adults is 0.5%-1.0%. This study aims to determine the prevalence of HCV infection among adolescents and young adults (AYA) accessing HIV/sexual health clinics.

METHODS

A cross-sectional study was conducted among AYA aged 15-24 years attending HIV/sexual health clinics in Bangkok, Thailand. The HCV infection prevalence, defined by anti-HCV antibody positivity using rapid diagnostic tests (SD BIOSENSOR, Korea), were reported with proportions and a 95% confidence interval (CI). Multivariate logistic regression was performed to identify factors associated with HCV infection.

RESULTS

From March to August 2023, 300 AYAs with a median age of 21 (interquartile range 20-23) years were enrolled into the study. One-third (29.7%) were people living with HIV (PLHIV). The overall prevalence of HCV infection was 2.7% (95%CI 1.2-5.2). Prevalence was higher among PLHIV (5.6%) compared to AYA without HIV (1.4%) (-value 0.053). The factor most significantly associated with HCV infection was people who used drugs (adjusted odds ratio 15.3, 95% CI 2.9-82.0, -value 0.001).

CONCLUSIONS

History of drug use was associated with the highest HCV infection prevalence. PLHIV had a trend of higher prevalence. HCV screening in HIV/sexual health clinics is recommended for early detection, treatment, and transmission reduction.

摘要

背景

泰国成年人中丙型肝炎病毒（HCV）感染率为0.5%-1.0%。本研究旨在确定在艾滋病病毒/性健康诊所就诊的青少年和青年（AYA）中HCV感染率。

方法

在泰国曼谷为15至24岁的AYA进行了一项横断面研究，这些人在艾滋病病毒/性健康诊所就诊。使用快速诊断检测（韩国SD BIOSENSOR公司）通过抗-HCV抗体阳性定义的HCV感染率，以比例和95%置信区间（CI）报告。进行多变量逻辑回归以确定与HCV感染相关的因素。

结果

2023年3月至8月，300名AYA纳入研究，中位年龄为21岁（四分位间距20-23岁）。三分之一（29.7%）为艾滋病病毒感染者（PLHIV）。HCV感染的总体患病率为2.7%（95%CI 1.2-5.2）。与未感染艾滋病病毒的AYA（1.4%）相比，PLHIV中的患病率更高（5.6%）（P值0.053）。与HCV感染最显著相关的因素是吸毒者（调整后的优势比为15.3，95%CI 2.9-82.0，P值0.001）。