Hernandez Manuel E, Motl Robert W, Foley Frederick W, Izzetoglu Meltem, Wagshul Mark, Holtzer Roee
Department of Biomedical and Translational Sciences, Carle Illinois College of Medicine, University of Illinois Urbana-Champaign, Urbana, IL, USA; Department of Kinesiology and Community Health, College of Applied Health Sciences, University of Illinois Urbana-Champaign, Urbana, IL, USA; Neuroscience Program, College of Liberal Arts & Sciences, University of Illinois Urbana-Champaign, Urbana, IL, USA; Beckman Institute, University of Illinois Urbana-Champaign, Urbana, IL, USA.
Department of Kinesiology and Nutrition, College of Applied Health Sciences, University of Illinois Chicago, Chicago, IL, USA.
Mult Scler Relat Disord. 2025 Jan;93:106224. doi: 10.1016/j.msard.2024.106224. Epub 2024 Dec 10.
BACKGROUND: There is limited research comparing both performance and brain control of walking between older adults with progressive and relapsing-remitting MS. OBJECTIVE: This study compared older adults with progressive and relapsing-remitting MS for differences in prefrontal cortex (PFC) activation in single- and dual-task-walking and practice-related effects on neural efficiency, walking, and cognitive performances. METHODS: Older adults with progressive (n = 32, age=65±6ys) and relapsing-remitting (n = 63, age=65±4ys) MS completed three conditions (single-task walk, single-task-alpha, i.e., cognitive interference task, and dual-task-walk) with three repeated trials wherein we measured PFC oxygenated hemoglobin (HbO), stride velocity and letter generation rate. Task, trial, and group effects and interactions were analyzed using linear mixed effects models. RESULTS: The task-related (i.e. single-to-dual task walking) increase in PFC HbO was greater in progressive than in relapsing-remitting MS (p < 0.001), while the practice-related decrease in dual-task PFC HbO was smaller in progressive than in relapsing-remitting MS (p < 0.001). Progressive MS was associated with slower stride velocity overall, but repeated trials resulted in faster stride velocity and correct letter generation rate for both groups. CONCLUSIONS: Practice-related improvements in cognitive and motor performances coupled with reduced PFC HbO over dual-task walking trials suggest attenuated improvements of efficiency in brain control of attention-demanding locomotion in progressive MS.
背景：比较进展型和复发缓解型多发性硬化症（MS）老年患者步行时的运动表现和大脑控制的研究有限。 目的：本研究比较进展型和复发缓解型MS老年患者在单任务和双任务步行时前额叶皮质（PFC）激活的差异，以及练习对神经效率、步行和认知表现的影响。 方法：进展型MS老年患者（n = 32，年龄=65±6岁）和复发缓解型MS老年患者（n = 63，年龄=65±4岁）完成三种条件（单任务步行、单任务阿尔法，即认知干扰任务，以及双任务步行），每种条件重复试验三次，在此期间我们测量PFC氧合血红蛋白（HbO）、步幅速度和字母生成率。使用线性混合效应模型分析任务、试验、组效应及相互作用。 结果：与任务相关的（即从单任务到双任务步行）PFC HbO增加在进展型MS中比在复发缓解型MS中更大（p < 0.001），而与练习相关的双任务PFC HbO降低在进展型MS中比在复发缓解型MS中小（p < 0.001）。总体而言，进展型MS与较慢的步幅速度相关，但重复试验使两组的步幅速度和正确字母生成率都加快了。 结论：在双任务步行试验中，与练习相关的认知和运动表现改善以及PFC HbO降低表明，进展型MS中对需要注意力的运动进行大脑控制的效率改善减弱。
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