Sprouse J S, Baker T
Proc Soc Exp Biol Med. 1985 Feb;178(2):304-8. doi: 10.3181/00379727-178-42014.
The muscle fasciculations caused by neostigmine and similar agents are the result of a primary drug action on motor nerve endings. Asynchronous, repetitive firing of action potentials are evoked at motor nerve endings which are then transmitted to muscle. A dose-response relationship between neostigmine dose and the rate of/or total neural activity has been established in the rat. This fasciculatory response to neostigmine can serve as an index of motor nerve ending excitability and may be useful in assessing the effects of certain pathological states or drug actions at the neuromuscular junction.
新斯的明及类似药物引起的肌肉束颤是药物对运动神经末梢产生原发性作用的结果。运动神经末梢会诱发动作电位的异步、重复发放，然后传递至肌肉。在大鼠中已建立新斯的明剂量与神经活动速率和/或总神经活动之间的剂量反应关系。这种对新斯的明的束颤反应可作为运动神经末梢兴奋性的指标，可能有助于评估某些病理状态或药物作用于神经肌肉接头的效果。
