Zhang Meng, Wei Jin, He Chang, Sui Liutao, Jiao Chucheng, Zhu Xiaoyan, Pan Xudong
Department of Neurology, The Affiliated Hospital of Qingdao University, Qingdao, 266000, China.
Department of Critical Care Medicine, The Affiliated Hospital of Qingdao University, Qingdao, 266000, China.
Cell Mol Biol Lett. 2024 Dec 18;29(1):153. doi: 10.1186/s11658-024-00669-4.
Mitochondria are versatile and complex organelles that can continuously communicate and interact with the cellular milieu. Deregulated communication between mitochondria and host cells/organelles has significant consequences and is an underlying factor of many pathophysiological conditions, including the process of aging. During aging, mitochondria lose function, and mitocellular communication pathways break down; mitochondrial dysfunction interacts with mitochondrial dyscommunication, forming a vicious circle. Therefore, strategies to protect mitochondrial function and promote effective communication of mitochondria can increase healthy lifespan and longevity, which might be a new treatment paradigm for age-related disorders. In this review, we comprehensively discuss the signal transduction mechanisms of inter- and intracellular mitochondrial communication, as well as the interactions between mitochondrial communication and the hallmarks of aging. This review emphasizes the indispensable position of inter- and intracellular mitochondrial communication in the aging process of organisms, which is crucial as the cellular signaling hubs. In addition, we also specifically focus on the status of mitochondria-targeted interventions to provide potential therapeutic targets for age-related diseases.
线粒体是多功能且复杂的细胞器，能够持续与细胞内环境进行交流和相互作用。线粒体与宿主细胞/细胞器之间失调的通讯会产生重大后果，并且是包括衰老过程在内的许多病理生理状况的潜在因素。在衰老过程中，线粒体功能丧失，线粒体与细胞的通讯途径瓦解；线粒体功能障碍与线粒体通讯障碍相互作用，形成恶性循环。因此，保护线粒体功能并促进线粒体有效通讯的策略可以延长健康寿命，这可能是治疗与年龄相关疾病的新范式。在这篇综述中，我们全面讨论了细胞间和细胞内线粒体通讯的信号转导机制，以及线粒体通讯与衰老特征之间的相互作用。本综述强调了细胞间和细胞内线粒体通讯在生物体衰老过程中不可或缺的地位，其作为细胞信号枢纽至关重要。此外，我们还特别关注了线粒体靶向干预的现状，为与年龄相关的疾病提供潜在的治疗靶点。
