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埃及一家三级眼科护理中心的耐药性角膜溃疡:10年流行病学研究

Resistant corneal ulcers in a tertiary care ophthalmic center in Egypt: 10 years epidemiological study.

作者信息

Khater Mohammad M, Nassef Mohammad Hosny, Elshorbagy Mohamed Sameh

机构信息

Ophthalmology Department, Tanta University Hospital, Gharbia Governorate 31527, Egypt.

出版信息

Int J Ophthalmol. 2024 Dec 18;17(12):2282-2287. doi: 10.18240/ijo.2024.12.17. eCollection 2024.

DOI:10.18240/ijo.2024.12.17
PMID:39697890
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11589440/
Abstract

AIM

To investigate the magnitude of problem caused by resistant corneal ulcers and its epidemiological characteristics.

METHODS

Patients with corneal lesions were selected and carefully examined and cases with resistant corneal ulcers were further investigated and data were recorded using a specific data sheet designed in hospital. Then, collected data from patients were statistically analyzed.

RESULTS

Totally 1939 cases were included in the study, including 816 fungal cases (42.1%) and 1123 (57.9%) non-fungal cases. Age of the participants ranged from 18 to 73y. Fungal cases were more common in middle age (35-55y). Men were more affected (53.5%) of cases included in the study. Keratomycosis affected more unskilled personnel (75.1%), large families with small houses (higher crowding index 73.9%), rural (64.5%) residence. Patients with sanitary water sources (34.8%) and waste disposal (24.4%) were less affected.

CONCLUSION

Keratomycosis is more frequent in unskilled personnel, rural locations, outdoor water sources and insanitary waste disposal systems. Corneal trauma and contact lens are common risk factors.

摘要

目的

探讨耐药性角膜溃疡所致问题的严重程度及其流行病学特征。

方法

选取角膜病变患者进行仔细检查,对耐药性角膜溃疡病例进一步调查,并使用医院设计的特定数据表记录数据。然后,对收集到的患者数据进行统计分析。

结果

本研究共纳入1939例病例,其中真菌性病例816例(42.1%),非真菌性病例1123例(57.9%)。参与者年龄在18至73岁之间。真菌性病例在中年(35 - 55岁)更为常见。男性受影响更多(占纳入研究病例的53.5%)。角膜真菌病在非技术人员中影响更大(75.1%),在房屋较小的大家庭(拥挤指数较高,73.9%)、农村地区(64.5%)更为常见。有卫生水源(34.8%)和废物处理设施(24.4%)的患者受影响较小。

结论

角膜真菌病在非技术人员、农村地区、户外水源和不卫生的废物处理系统中更为常见。角膜外伤和隐形眼镜是常见的危险因素。

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本文引用的文献

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Application of Metagenomic Next-Generation Sequencing in the Diagnosis of Infectious Keratitis.宏基因组下一代测序在感染性角膜炎诊断中的应用。
J Ophthalmol. 2024 Apr 29;2024:9911979. doi: 10.1155/2024/9911979. eCollection 2024.
2
Pentoxifylline treats Aspergillus fumigatus keratitis by reducing fungal burden and suppressing corneal inflammation.己酮可可碱通过减轻真菌负荷和抑制角膜炎症来治疗烟曲霉性角膜炎。
Eur J Pharmacol. 2023 Apr 15;945:175607. doi: 10.1016/j.ejphar.2023.175607. Epub 2023 Feb 21.
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Shotgun metagenomic sequencing in culture negative microbial keratitis.培养阴性微生物性角膜炎中的鸟枪法宏基因组测序
Eur J Ophthalmol. 2023 Jul;33(4):1589-1595. doi: 10.1177/11206721221149077. Epub 2023 Jan 8.
4
Multidrug-resistant keratitis: challenging yet manageable.多药耐药性角膜炎:具有挑战性但可管理。
Br J Ophthalmol. 2023 Jun;107(6):769-773. doi: 10.1136/bjophthalmol-2021-320203. Epub 2022 Mar 28.
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Epidemiology, Microbiology, and Genetics of Contact Lens-Related and Non-Contact Lens-Related Infectious Keratitis.接触镜相关和非接触镜相关感染性角膜炎的流行病学、微生物学和遗传学。
Eye Contact Lens. 2022 Mar 1;48(3):127-133. doi: 10.1097/ICL.0000000000000884.
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Fungal keratitis: A review of clinical presentations, treatment strategies and outcomes.真菌性角膜炎:临床表现、治疗策略及预后综述
Ocul Surf. 2022 Apr;24:22-30. doi: 10.1016/j.jtos.2021.12.001. Epub 2021 Dec 13.
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Fungal keratitis: Mechanisms of infection and management strategies.真菌性角膜炎:感染机制与治疗策略。
Surv Ophthalmol. 2022 May-Jun;67(3):758-769. doi: 10.1016/j.survophthal.2021.08.002. Epub 2021 Aug 20.
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Outcomes of Microbial Keratitis Cases Resistant to Antimicrobials in Sydney, Australia.澳大利亚悉尼对抗生素耐药的微生物角膜炎病例的结果。
Cornea. 2022 May 1;41(5):572-578. doi: 10.1097/ICO.0000000000002803.
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The global incidence and diagnosis of fungal keratitis.真菌性角膜炎的全球发病与诊断。
Lancet Infect Dis. 2021 Mar;21(3):e49-e57. doi: 10.1016/S1473-3099(20)30448-5. Epub 2020 Oct 22.
10
Recent advances on mycotic keratitis caused by dematiaceous hyphomycetes.暗色丝孢霉所致真菌性角膜炎的最新进展。
J Appl Microbiol. 2021 Oct;131(4):1652-1667. doi: 10.1111/jam.15008. Epub 2021 Feb 9.