González-González Layla Grecia, Panameño-Cruz Vicente, Luna-Arias Juan Pedro, Reyna-Beltrán Elizabeth
Faculty of Medicine "Dr. Alberto Romo Caballero" Autonomous University of Tamaulipas Tampico Mexico.
Department of Cell Biology Center for Research and Advanced Studies of the National Polytechnic Institute (Cinvestav-IPN) Mexico City Mexico.
Clin Case Rep. 2024 Dec 18;12(12):e70016. doi: 10.1002/ccr3.70016. eCollection 2024 Dec.
Multiple sclerosis (MS) is an autoimmune demyelinating disease that affects the central nervous system (CNS) with its chronic inflammatory component. In the treatment of MS, corticosteroids are usually implemented to reduce the disease's inflammation rate. In this case study, we present a patient with MS that initially received corticosteroids, which heightened his vulnerability to infections, particularly respiratory ones. Consequently, the treatment was changed to the administration of dialyzable leukocyte extract (DLE) "Oral Transferon". To this day, the rate of inflammation has been reduced, slowing the evolution of MS, decreasing the clinical manifestations of the disease, and improving the patient's quality of life. This may be attributed to the immunomodulatory effects of the Transferon. More studies are needed in MS patients implementing a treatment based solely on Transferon to establish its effectiveness as an immunomodulator (specifically for this autoimmune disease).
多发性硬化症(MS)是一种自身免疫性脱髓鞘疾病,其慢性炎症成分会影响中枢神经系统(CNS)。在MS的治疗中,通常会使用皮质类固醇来降低疾病的炎症发生率。在本病例研究中,我们介绍了一名MS患者,该患者最初接受了皮质类固醇治疗,这增加了他对感染的易感性,尤其是呼吸道感染。因此,治疗改为给予可透析白细胞提取物(DLE)“口服转移因子”。时至今日,炎症发生率已降低,减缓了MS的进展,减少了疾病的临床表现,并改善了患者的生活质量。这可能归因于转移因子的免疫调节作用。在仅基于转移因子进行治疗的MS患者中,还需要更多研究来确定其作为免疫调节剂(特别是针对这种自身免疫性疾病)的有效性。