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对于气道可能存在困难的患者,经咽气管插管通气与面罩通气的有效性比较:一项随机、交叉、盲法试验

Effectiveness of Ventilation via an Endotracheal Tube in Pharynx Versus a Facemask in Patients With Potentially Difficult Airway: A Randomized, Crossover, and Blind Trial.

作者信息

Markham Travis, AlFarra Abraham S, Tejani Mubeen, Tate Daniel J, Barrera Jose E, Paladugu Sreelekha, Saroukhani Sepideh, Jiang Yandong

机构信息

From the Department of Anesthesiology, McGovern Medical School, the University of Texas Health Science Center at Houston, Houston, Texas.

Department of Anesthesiology and Pain Management, Cleveland Clinic, Cleveland, Ohio.

出版信息

Anesth Analg. 2025 Feb 1;140(2):280-289. doi: 10.1213/ANE.0000000000007273. Epub 2024 Dec 20.

Abstract

BACKGROUND

The difficult airway is frequently encountered across many scenarios. The extreme form is a "cannot intubate and cannot oxygenate" scenario, which lacks a reliable rescue technique. Previous case reports or studies with small sample sizes indicate the feasibility and efficiency of an endotracheal tube in the pharynx (TTIP) to ventilate patients. We hypothesize that ventilation via TTIP is an effective rescue technique for failed mask ventilation.

METHOD

One hundred forty-seven patients with potentially difficult airways were randomly assigned to the sequence (Tube first) of tube first ventilation via TTIP for 1 minute after induction, followed by via mask ventilation for 1 minute or in reverse sequence (Mask first). The ventilation was done with pressure control mode, a peak inspiratory airway pressure of 20 cmH 2 O, an inspiratory to expiratory time ratio of 1:2, and a respiratory rate of 10 breaths/min.

RESULTS

A total of 136 patients underwent final analysis. The overall success rate (primary outcome) of ventilation via TTIP and mask, defined as the presence of expired carbon dioxide, was 93.4% (127/136) and 84.6% (115/136), respectively ( P = .02). The success rate, 85.7% (6/7), of mask ventilation rescuing a failed TTIP ventilation and 100% (13/13) of TTIP rescuing a failed mask ventilation were comparable ( P = .35).

CONCLUSIONS

The success rates of TTIP and mask ventilation are comparable. Ventilation via TTIP could be an alternative rescue technique for managing a difficult airway.

摘要

背景

在多种情况下经常会遇到困难气道。最极端的情况是“无法插管且无法给氧”,目前缺乏可靠的挽救技术。既往的病例报告或小样本研究提示,经咽气管导管通气(TTIP)用于患者通气具有可行性和有效性。我们推测,TTIP通气是处理面罩通气失败的一种有效挽救技术。

方法

147例存在潜在困难气道的患者被随机分配至诱导后先通过TTIP通气1分钟,随后通过面罩通气1分钟的顺序组(先导管组)或相反顺序组(先面罩组)。通气采用压力控制模式,吸气峰压20 cmH₂O,吸呼比1:2,呼吸频率10次/分钟。

结果

共有136例患者接受最终分析。TTIP通气和面罩通气的总体成功率(主要结局,定义为呼出二氧化碳的存在)分别为93.4%(127/136)和84.6%(115/136)(P = 0.02)。面罩通气挽救TTIP通气失败的成功率为85.7%(6/7),TTIP挽救面罩通气失败的成功率为100%(13/13),二者具有可比性(P = 0.35)。

结论

TTIP通气和面罩通气的成功率具有可比性。TTIP通气可作为处理困难气道的一种替代挽救技术。

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