Wu Xiao, Wu Hao, Zhong Mengli, Chen Yixuan, Su Weiwei, Li Peibo
Guangdong Engineering and Technology Research Center for Quality and Efficacy Re-Evaluation of Post-Marketed TCM, Guangdong Provincial Key Laboratory of Plant Stress Biology, State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-sen University, Guangzhou 510275, PR China.
Guangdong Engineering and Technology Research Center for Quality and Efficacy Re-Evaluation of Post-Marketed TCM, Guangdong Provincial Key Laboratory of Plant Stress Biology, State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-sen University, Guangzhou 510275, PR China.
Fitoterapia. 2025 Mar;181:106353. doi: 10.1016/j.fitote.2024.106353. Epub 2024 Dec 19.
Epigenetics refers to heritable changes in gene expression or phenotypic changes that occur without changing the gene sequence. The main methods of epigenetics include non-coding RNA, histone modification, and DNA modification, which play an essential role in gene expression regulation and even the occurrence of diverse diseases. Naringenin, the aglycone form of naringin, is a natural flavonoid compound mainly found in fruits or plant derivatives such as citrus, tomatoes, and cherries. Naringenin and naringin exhibit a broad spectrum of biological activities and pharmacological effects, including anti-cancer, cardiovascular disease improving, anti-inflammatory, and anti-oxidant activities, all of which are advantageous for human health. Recent studies have uncovered that naringenin and naringin influence gene expression by modulating epigenetic pathways, including microRNA (miRNA) regulation. This mechanism plays a crucial role in the therapeutic potential for various diseases. This paper reviews the epigenetic researches on the physiological activities of naringenin and naringin. It highlights how these compounds can exert diverse effects through different signaling pathways, thereby ameliorating associated diseases. These findings provide valuable insights for the future applications of naringenin and naringin.
表观遗传学是指在不改变基因序列的情况下发生的基因表达的可遗传变化或表型变化。表观遗传学的主要方法包括非编码RNA、组蛋白修饰和DNA修饰，它们在基因表达调控乃至多种疾病的发生中起着至关重要的作用。柚皮素是柚皮苷的苷元形式，是一种天然黄酮类化合物，主要存在于水果或植物衍生物中，如柑橘、番茄和樱桃。柚皮素和柚皮苷具有广泛的生物活性和药理作用，包括抗癌、改善心血管疾病、抗炎和抗氧化活性，所有这些都对人类健康有益。最近的研究发现，柚皮素和柚皮苷通过调节表观遗传途径影响基因表达，包括微小RNA（miRNA）调控。这一机制在各种疾病的治疗潜力中起着关键作用。本文综述了关于柚皮素和柚皮苷生理活性的表观遗传学研究。它强调了这些化合物如何通过不同的信号通路发挥多种作用，从而改善相关疾病。这些发现为柚皮素和柚皮苷的未来应用提供了有价值的见解。
