Aldemir Muhammed Ebuzer, Aksakalli Tugay, Demirdogen Saban Oguz, Altay Mehmet Sefa, Ozbey Isa
University of Health Sciences, Kayseri City Hospital, Department of Urology, Kayseri, Turkey.
University of Health Sciences, Erzurum Regional Training and Research Hospital, Department of Urology, Erzurum, Turkey.
Urology. 2025 Mar;197:101-107. doi: 10.1016/j.urology.2024.12.031. Epub 2024 Dec 20.
To compare sperm retrieval rates (SRR), postoperative pain, testicular volume, and postoperative testosterone levels between equatorial incisional microdissection testicular sperm extraction (micro-TESE) and longitidunal incisional micro-TESE in nonobstructive azoospermic (NOA) patients.
Fifty NOA patients undergoing equatorial incisional micro-TESE were retrospectively assigned to group 1, while 50 patients undergoing longitidunal incisional micro-TESE were prospectively assigned to group 2. Demographic data, operative time, postoperative pain assessed via the visual analog scale, complications, SRR, and hormonal evaluations (FSH, LH, total testosterone) were recorded. Both groups compared in terms of preoperative demographic and clinical characteristics. SRR, testicular volume and postoperative testosterone, FSH, LH compared between study groups.
SRR were significantly higher in group 2 (62%) compared to group 1 (42%) (P=.045). No significant differences in operative time, visual analog scale pain scores, or postoperative complications were observed between groups. Hormonal evaluations showed a statistically significant decrease in testosterone levels for both groups at 3months, but no significant differences between groups. Testicular volume decreased postoperatively in both groups, with no significant differences between them.
Longitidunal incisional micro-TESE significantly improves SRR without increasing complication rates compared to equatorial incisional micro-TESE. These findings suggest that the longitidunal incisional micro-TESE may be a valuable advancement in the surgical management of NOA patients, warranting further research and clinical validation.
比较非梗阻性无精子症(NOA)患者经赤道切口显微外科睾丸精子提取术(micro-TESE)和经纵向切口micro-TESE的精子获取率(SRR)、术后疼痛、睾丸体积及术后睾酮水平。
回顾性选取50例行赤道切口micro-TESE的NOA患者作为1组,前瞻性选取50例行纵向切口micro-TESE的患者作为2组。记录人口统计学数据、手术时间、通过视觉模拟量表评估的术后疼痛、并发症、SRR及激素评估指标(促卵泡生成素、促黄体生成素、总睾酮)。比较两组术前的人口统计学和临床特征。比较研究组间的SRR、睾丸体积及术后睾酮、促卵泡生成素、促黄体生成素水平。
2组的SRR(62%)显著高于1组(42%)(P = 0.045)。两组间手术时间、视觉模拟量表疼痛评分或术后并发症无显著差异。激素评估显示,两组在术后3个月时睾酮水平均有统计学意义的下降,但组间无显著差异。两组术后睾丸体积均减小,且两组间无显著差异。
与赤道切口micro-TESE相比,纵向切口micro-TESE可显著提高SRR,且不增加并发症发生率。这些发现表明,纵向切口micro-TESE可能是NOA患者手术治疗中的一项有价值的进展,值得进一步研究和临床验证。