APOE4对暴露于短裸甲藻神经毒素后神经症状的影响。
The impact of APOE4 on neurological symptoms after exposure to K. brevis neurotoxin.
作者信息
Aldrich Gregory J, Nkiliza Aurore, Ferguson Scott, Niedospial Daniel, Helgager Dakota, Keegan Andrew P, Paris Daniel, Kirkpatrick Barbara, Crawford Fiona, Mullan Michael, Abdullah Laila
机构信息
Roskamp Institute, 2040 Whitfield Ave, Sarasota, FL, USA; James A. Haley VA Hospital, Tampa, FL, USA.
Roskamp Institute, 2040 Whitfield Ave, Sarasota, FL, USA.
出版信息
Environ Toxicol Pharmacol. 2025 Jan;113:104621. doi: 10.1016/j.etap.2024.104621. Epub 2024 Dec 20.
INTRODUCTION
The harmful alga Karenia brevis (K. brevis) releases brevetoxins (PbTx) that cause respiratory and neurological symptoms. The apolipoprotein E (APOE) ε4 allele has been linked to poor neurological outcomes after exposure to environmental toxicants. This study explores the influence of the ε4 allele on the relationship between K. brevis in coastal waters and neurological symptoms reported by Southwest Florida residents.
METHODS
A Surrogate Brevetoxin Exposure (SBE) index was developed to estimate aerosolized PbTx exposure. Data on past medical history and symptoms and blood for analyzing APOE genotypes were collected from 244 participants.
RESULTS
Compared to non-carriers, ε4 carriers more frequently reported experiencing memory problems and fatigue during red tide blooms, independent of conditions like dementia and chronic fatigue syndrome.
CONCLUSION
This study suggests that the ε4 allele may exacerbate neurological symptoms from aerosolized PbTx, highlighting the need for strategies to better understand the impact of PbTx on the brain.
引言
有害藻类短裸甲藻（Karenia brevis，简称K. brevis）会释放短裸甲藻毒素（PbTx），引发呼吸道和神经症状。载脂蛋白E（APOE）ε4等位基因与接触环境毒物后不良的神经学转归有关。本研究探讨ε4等位基因对沿海水域短裸甲藻与佛罗里达州西南部居民报告的神经症状之间关系的影响。
方法
制定了替代短裸甲藻毒素暴露（SBE）指数，以估计雾化的PbTx暴露情况。从244名参与者收集了既往病史、症状数据以及用于分析APOE基因型的血液样本。
结果
与非携带者相比，ε4携带者在赤潮期间更频繁地报告出现记忆问题和疲劳，且与痴呆和慢性疲劳综合征等情况无关。
结论
本研究表明，ε4等位基因可能会加剧雾化PbTx所致的神经症状，凸显了采取策略以更好地了解PbTx对大脑影响的必要性。
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