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-5,15-双[3-(异亚丙基半乳糖吡喃氧基)苯基]-10,20-双(4-甲基苯基)卟啉

-5,15-Bis[3-(iso-propyl-idenegalacto-pyran-oxy)phen-yl]-10,20-bis-(4-methyl-phen-yl)porphyrin.

作者信息

Vinodh Mickey, Alipour Fatemeh H, Al-Azemi Talal F

机构信息

Department of Chemistry, Kuwait University, PO Box 5969, Safat 13060, Kuwait.

出版信息

IUCrdata. 2024 Oct 24;9(Pt 10):x241028. doi: 10.1107/S2414314624010289. eCollection 2024 Oct.

Abstract

The crystal structure of a glycosyl-ated porphyrin () system, CHNO, where two iso-propyl-idene protected galactose moieties are attached to the position of a substituted tetra-aryl porphyrin is reported. This structure reveals that the parent porphyrin is planar, with the galactose moieties positioned above and below the porphyrin macrocycle. This orientation likely prevents porphyrin-porphyrin H-type aggregation, potentially enhancing its efficiency as a photosensitizer in photodynamic therapy. Notable non-bonding C-H⋯O and C-H⋯π inter-actions among adjacent systems are observed in this crystal network. Additionally, the tolyl groups of each porphyrin can engage in π-π inter-actions with the delocalized π-systems of neighboring porphyrins.

摘要

报道了一种糖基化卟啉()体系CHNO的晶体结构,其中两个异丙叉基保护的半乳糖部分连接到取代的四芳基卟啉的位置。该结构表明母体卟啉是平面的,半乳糖部分位于卟啉大环的上方和下方。这种取向可能会阻止卟啉-卟啉H型聚集,从而有可能提高其在光动力疗法中作为光敏剂的效率。在该晶体网络中观察到相邻体系之间显著的非键C-H⋯O和C-H⋯π相互作用。此外,每个卟啉的甲苯基可与相邻卟啉的离域π体系发生π-π相互作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/139f/11660175/14a03be2406c/x-09-x241028-fig1.jpg

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