Nordrehaug J E, Johannessen K A, von der Lippe G
Circulation. 1985 Apr;71(4):645-9. doi: 10.1161/01.cir.71.4.645.
Sixty patients with a first acute myocardial infarction and no current treatment with cardioactive drugs were included in a prospective study of the relationship between serum potassium concentration and the early occurrence of ventricular tachycardia and premature ventricular contractions (PVCs). Serum potassium level (range 2.5 to 5 mmol/liter) was estimated 3.8 +/- 2.5 hr (mean +/- SD) after the onset of the infarction, and Holter monitoring was performed during the subsequent 12 hr. In multivariate analysis, serum potassium level was negatively and age positively related to ventricular tachycardia. Among the subclasses of PVCs (frequent unifocal, multifocal, couplets, bigeminy), serum potassium concentration was negatively related to the frequent unifocal subclass; hypertension was related to couplets and to the presence of any of the subclasses, and serum aspartate aminotransferase concentration was related to multifocal PVCs. Heart failure leading to death was related to all subclasses of PVC. Serum potassium concentration is an independent inverse predictor of the occurrence of ventricular tachycardia and frequent unifocal PVCs early in acute myocardial infarction.
60例首次发生急性心肌梗死且目前未使用抗心律失常药物治疗的患者被纳入一项前瞻性研究，以探讨血清钾浓度与室性心动过速和室性早搏（PVCs）早期发生之间的关系。在梗死发作后3.8±2.5小时（平均值±标准差）测定血清钾水平（范围为2.5至5 mmol/升），并在随后的12小时内进行动态心电图监测。在多变量分析中，血清钾水平与室性心动过速呈负相关，年龄与室性心动过速呈正相关。在PVCs的亚类（频发单源性、多源性、成对、二联律）中，血清钾浓度与频发单源性亚类呈负相关；高血压与成对及任何亚类的存在有关，血清天冬氨酸转氨酶浓度与多源性PVCs有关。导致死亡的心力衰竭与PVCs的所有亚类有关。血清钾浓度是急性心肌梗死早期室性心动过速和频发单源性PVCs发生的独立反向预测指标。
